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• W171755153 abstract "Hypoxia-inducible factors-1α (HIF-lα) and HIF-2α are important proteins initiating tumor cell responses to hypoxia. Specifically, the transcription of genes related to erythropoiesis, glycolysis, and angiogenesis depends on the rate of HIFα binding to DNA at the hypoxia response elements of target genes. In this study, the authors evaluated the immunohistochemical expression of HIF-2α in 62 infiltrating ductal carcinomas of the breast, not otherwise specified, in relation to estrogen and progesterone receptors, the MIB1 proliferation index, the vascular density, and the proteins c-erbB-2, bcl-2, and p53. Extensive and strong cytoplasmic and/or nuclear expression of HIF-2α was noted in 23 of the 64 (35.9%) cases, and this was associated with increased vascular density (P=0.0002), increased c-erbB-2 membrane expression (P=0.02), and secondary deposits to multiple axillary lymph nodes (>3). In multivariate analysis, HIF-2α and T stage were the only variables related to extensive nodal metastasis. The authors conclude that HIF-2α overexpression, a common event in infiltrating ductal carcinomas of the breast, is related to high metastatic potential via increased angiogenic and c-erbB-2 activity." @default.
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• W171755153 date "2006-03-01" @default.
• W171755153 modified "2023-09-26" @default.
• W171755153 title "Hypoxia-Inducible Factor-2α (HIF-2α) Induces Angiogenesis in Breast Carcinomas" @default.
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• W171755153 doi "https://doi.org/10.1097/01.pai.0000145182.98577.10" @default.
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