Matches in SemOpenAlex for { <https://semopenalex.org/work/W1717592064> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1717592064 endingPage "144" @default.
- W1717592064 startingPage "138" @default.
- W1717592064 abstract "Bone to mechanical loading elicits a biological response that has clinical significance for several areas in dental medicine, including orthodontic tooth movement, tempromandibular joint disease, and endosseous dental implant osseointegration. Human orthopedic studies of failed hip implant sites have identified increased mRNA expression of several collagen-degrading matrix metalloproteinases (MMPs), while in vitro experiments have shown increases in MMP secretion after exposure to inflammatory mediators. This investigation evaluates the effects of mechanical deformation on in vitro osteoblasts by assessing changes in MMP gene expression and enzyme activity. We seeded mouse neonatal calvarial osteoblasts onto flexible 6-well plates and subjected to continuous cyclic mechanical stretching. The expression and activity of mRNA for several MMPs (2, 3, 9, and 10) was assessed. When subjected to mechanical stress in culture, only mRNA specific for MMP-9 was significantly increased compared to nonstretched controls (P < .005). Measurement of MMP activity by gelatin zymography demonstrated that none of the MMPs showed increased activity with stretching; however, MMP-2 activity decreased. Our results suggest that in response to stretch, MMP-2 responds rapidly by inhibiting conversion of a MMP-2 to the active form, while a slower up-regulation of MMP-9 may play a role in the long-term remodeling of extracellular matrix in response to continuous mechanical loading. This study suggests that the regulation of metalloproteinases at both the mRNA and protein level are important in the response of bone to mechanical stress." @default.
- W1717592064 created "2016-06-24" @default.
- W1717592064 creator A5004256871 @default.
- W1717592064 creator A5012026016 @default.
- W1717592064 creator A5027295059 @default.
- W1717592064 creator A5042230007 @default.
- W1717592064 date "2016-04-01" @default.
- W1717592064 modified "2023-09-27" @default.
- W1717592064 title "Mechanical Stretching of Mouse Calvarial Osteoblasts In Vitro Models Changes in MMP-2 and MMP-9 Expression at the Bone-Implant Interface" @default.
- W1717592064 cites W1546229037 @default.
- W1717592064 cites W1966171234 @default.
- W1717592064 cites W1975486727 @default.
- W1717592064 cites W1977127210 @default.
- W1717592064 cites W1980832852 @default.
- W1717592064 cites W1994233268 @default.
- W1717592064 cites W1995220379 @default.
- W1717592064 cites W2007287226 @default.
- W1717592064 cites W2021753367 @default.
- W1717592064 cites W2031912912 @default.
- W1717592064 cites W2031930348 @default.
- W1717592064 cites W2033415009 @default.
- W1717592064 cites W2036834425 @default.
- W1717592064 cites W2049220062 @default.
- W1717592064 cites W2056507563 @default.
- W1717592064 cites W2061896339 @default.
- W1717592064 cites W2090775822 @default.
- W1717592064 cites W2091038187 @default.
- W1717592064 cites W2091484559 @default.
- W1717592064 cites W2108082833 @default.
- W1717592064 cites W2133562234 @default.
- W1717592064 cites W2135124706 @default.
- W1717592064 cites W2137388287 @default.
- W1717592064 doi "https://doi.org/10.1563/aaid-joi-d-14-00199" @default.
- W1717592064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25961753" @default.
- W1717592064 hasPublicationYear "2016" @default.
- W1717592064 type Work @default.
- W1717592064 sameAs 1717592064 @default.
- W1717592064 citedByCount "5" @default.
- W1717592064 countsByYear W17175920642016 @default.
- W1717592064 countsByYear W17175920642019 @default.
- W1717592064 countsByYear W17175920642020 @default.
- W1717592064 countsByYear W17175920642021 @default.
- W1717592064 crossrefType "journal-article" @default.
- W1717592064 hasAuthorship W1717592064A5004256871 @default.
- W1717592064 hasAuthorship W1717592064A5012026016 @default.
- W1717592064 hasAuthorship W1717592064A5027295059 @default.
- W1717592064 hasAuthorship W1717592064A5042230007 @default.
- W1717592064 hasConcept C101414908 @default.
- W1717592064 hasConcept C109523444 @default.
- W1717592064 hasConcept C126322002 @default.
- W1717592064 hasConcept C136229726 @default.
- W1717592064 hasConcept C141071460 @default.
- W1717592064 hasConcept C170033053 @default.
- W1717592064 hasConcept C177430391 @default.
- W1717592064 hasConcept C185592680 @default.
- W1717592064 hasConcept C189165786 @default.
- W1717592064 hasConcept C2781411149 @default.
- W1717592064 hasConcept C55493867 @default.
- W1717592064 hasConcept C71924100 @default.
- W1717592064 hasConcept C86803240 @default.
- W1717592064 hasConcept C95444343 @default.
- W1717592064 hasConceptScore W1717592064C101414908 @default.
- W1717592064 hasConceptScore W1717592064C109523444 @default.
- W1717592064 hasConceptScore W1717592064C126322002 @default.
- W1717592064 hasConceptScore W1717592064C136229726 @default.
- W1717592064 hasConceptScore W1717592064C141071460 @default.
- W1717592064 hasConceptScore W1717592064C170033053 @default.
- W1717592064 hasConceptScore W1717592064C177430391 @default.
- W1717592064 hasConceptScore W1717592064C185592680 @default.
- W1717592064 hasConceptScore W1717592064C189165786 @default.
- W1717592064 hasConceptScore W1717592064C2781411149 @default.
- W1717592064 hasConceptScore W1717592064C55493867 @default.
- W1717592064 hasConceptScore W1717592064C71924100 @default.
- W1717592064 hasConceptScore W1717592064C86803240 @default.
- W1717592064 hasConceptScore W1717592064C95444343 @default.
- W1717592064 hasIssue "2" @default.
- W1717592064 hasLocation W17175920641 @default.
- W1717592064 hasLocation W17175920642 @default.
- W1717592064 hasOpenAccess W1717592064 @default.
- W1717592064 hasPrimaryLocation W17175920641 @default.
- W1717592064 hasRelatedWork W2034421648 @default.
- W1717592064 hasRelatedWork W2068876393 @default.
- W1717592064 hasRelatedWork W2082049657 @default.
- W1717592064 hasRelatedWork W2091139028 @default.
- W1717592064 hasRelatedWork W2094755758 @default.
- W1717592064 hasRelatedWork W2126562747 @default.
- W1717592064 hasRelatedWork W2389601191 @default.
- W1717592064 hasRelatedWork W2432861292 @default.
- W1717592064 hasRelatedWork W3119031593 @default.
- W1717592064 hasRelatedWork W4225986885 @default.
- W1717592064 hasVolume "42" @default.
- W1717592064 isParatext "false" @default.
- W1717592064 isRetracted "false" @default.
- W1717592064 magId "1717592064" @default.
- W1717592064 workType "article" @default.