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- W171772620 abstract "Proper comparison of the therapeutic efficacy of subthalamic nucleus (STN) deep brain stimulation (DBS) vs globus pallidus internus (GPi) DBS is not possible with the information currently available. Multi-center randomized studies are in progress that may settle this point. Despite this, the choice of GPi as a surgical target has decreased enormously in practice and most recent studies concern data derived from patients treated with STN DBS. Why this has occurred cannot be entirely explained on scientific grounds. Perhaps the larger number of experimental studies demonstrating the impact of STN stimulation on parkinsonism as well as the anatomo-physiological data indicating the prominent capacity of the STN to modulate basal ganglia output created a scenario that has led specialists to prefer the STN. Finally, the ability to reduce or even discontinue levodopa and other antiparkinson treatments after STN DBS undoubtedly has had a major influence on its relative popularity." @default.
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- W171772620 date "2008-01-01" @default.
- W171772620 modified "2023-10-18" @default.
- W171772620 title "Deep Brain Stimulation of the Globus Pallidus Pars Interna and Subthalamic Nucleus in Parkinson's Disease: Pros and Cons" @default.
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