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- W171797676 abstract "The relationship between β-adrenoceptor mediated relaxation and the cyclic AMP system has been studied in rabbit colon muscle. The relaxation is closely associated to stimulation of the enzymes adenylate cyclase and protein kinase. Calcium binding and membrane phosphorylation of subcellular membranes were stimulated by cyclic AMP. We therefore suggest that activation of the cyclic AMP-protein kinase system is an important step for one of the mechanisms regulating the smooth muscle tone. The mediator role of cyclic GMP is under discussion. Our data is inconsistent with a relaxant function of cyclic GMP at least in rabbit colon and guinea-pig vas deferens. Some of our experiments indicated that cyclic GMP may be responsible for promotion of contractions. Further work is needed to clarify the role of cyclic GMP in smooth muscle function." @default.
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- W171797676 date "1979-01-01" @default.
- W171797676 modified "2023-10-17" @default.
- W171797676 title "CYCLIC NUCLEOTIDES AND CONTRACTION-RELAXATION REGULATION IN SMOOTH MUSCLE" @default.
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- W171797676 doi "https://doi.org/10.1016/b978-0-08-023178-5.50030-6" @default.
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