Matches in SemOpenAlex for { <https://semopenalex.org/work/W171848939> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W171848939 abstract "West Nile Virus (WNV) has emerged as a major cause of viral encephalitis. Since its outbreak in the United States 27,000 people have presented with clinical WNV disease resulting in 1074 fatalities. WNV causes a range of disease from mild febrile illnesses to severe and fatal encephalitis. To date, there are currently no therapeutic agents or vaccines available to treat WNV infection in humans. In order to address this, a better understanding of the mechanisms responsible for viral neuroinvasion and neuropathology are required. Using a range of in vitro and in vivo studies, we have investigated the routes by which WNV enters the CNS. Virus replication was observed in the brain microvascular endothelial cells in mice that succumbed to WNV encephalitis. Moreover, we demonstrated that infection of a polarized HBMEC with WNV induced apoptosis. Microarray analysis of WNV-infected HBMEC’s revealed that WNV elicited the expression of cytokines that have been shown to contribute to permeablization of the BBB. These findings suggest that WNV can enter the CNS through the BBB via multiple mechanisms. Real-time RT-PCR performed on WNVinfected HBMECs identified two host genes involved in the host cellular anti-oxidant response that were differentially regulated during viral infection. Furthermore, the addition of the antioxidant, N-acetylcysteine, restored cell viability and decreased viral replication, indicating that oxidative stress contributes to WNV-induced pathogenesis. The current state of knowledge regarding the pathogenesis of WNV encephalitis is based on studies that have defined the role of systemic immune responses to WNV. Limited investigations have been undertaken to determine the contribution of brain cells in the defence, or damage to the brain once WNV has gained access to the CNS. Real-time RT-PCR results in conjunction with in vivo CBA assay data, suggested several candidate host genes that could contribute to the pathogenesis of WNV. Thus, it is necessary to further define the mechanisms of WNV induced pathogenesis as this will aid in the development of targeted strategies to prevent neurological infection and mitigate neurological diseases in affected individuals." @default.
- W171848939 created "2016-06-24" @default.
- W171848939 creator A5043588748 @default.
- W171848939 date "2009-09-01" @default.
- W171848939 modified "2023-09-27" @default.
- W171848939 title "The Neuroinvasion and Neuropathology of West Nile virus" @default.
- W171848939 hasPublicationYear "2009" @default.
- W171848939 type Work @default.
- W171848939 sameAs 171848939 @default.
- W171848939 citedByCount "0" @default.
- W171848939 crossrefType "journal-article" @default.
- W171848939 hasAuthorship W171848939A5043588748 @default.
- W171848939 hasConcept C116675565 @default.
- W171848939 hasConcept C140704245 @default.
- W171848939 hasConcept C140933497 @default.
- W171848939 hasConcept C142724271 @default.
- W171848939 hasConcept C159047783 @default.
- W171848939 hasConcept C203014093 @default.
- W171848939 hasConcept C2522874641 @default.
- W171848939 hasConcept C2779134260 @default.
- W171848939 hasConcept C2779734145 @default.
- W171848939 hasConcept C2780130745 @default.
- W171848939 hasConcept C2780942790 @default.
- W171848939 hasConcept C71924100 @default.
- W171848939 hasConcept C83455156 @default.
- W171848939 hasConcept C86803240 @default.
- W171848939 hasConcept C8891405 @default.
- W171848939 hasConceptScore W171848939C116675565 @default.
- W171848939 hasConceptScore W171848939C140704245 @default.
- W171848939 hasConceptScore W171848939C140933497 @default.
- W171848939 hasConceptScore W171848939C142724271 @default.
- W171848939 hasConceptScore W171848939C159047783 @default.
- W171848939 hasConceptScore W171848939C203014093 @default.
- W171848939 hasConceptScore W171848939C2522874641 @default.
- W171848939 hasConceptScore W171848939C2779134260 @default.
- W171848939 hasConceptScore W171848939C2779734145 @default.
- W171848939 hasConceptScore W171848939C2780130745 @default.
- W171848939 hasConceptScore W171848939C2780942790 @default.
- W171848939 hasConceptScore W171848939C71924100 @default.
- W171848939 hasConceptScore W171848939C83455156 @default.
- W171848939 hasConceptScore W171848939C86803240 @default.
- W171848939 hasConceptScore W171848939C8891405 @default.
- W171848939 hasLocation W1718489391 @default.
- W171848939 hasOpenAccess W171848939 @default.
- W171848939 hasPrimaryLocation W1718489391 @default.
- W171848939 hasRelatedWork W144385517 @default.
- W171848939 hasRelatedWork W156880304 @default.
- W171848939 hasRelatedWork W1843120170 @default.
- W171848939 hasRelatedWork W2220807044 @default.
- W171848939 hasRelatedWork W2406941593 @default.
- W171848939 hasRelatedWork W2474892888 @default.
- W171848939 hasRelatedWork W2594356439 @default.
- W171848939 hasRelatedWork W2608721412 @default.
- W171848939 hasRelatedWork W2745986761 @default.
- W171848939 hasRelatedWork W2794981626 @default.
- W171848939 hasRelatedWork W2885264408 @default.
- W171848939 hasRelatedWork W2913240973 @default.
- W171848939 hasRelatedWork W2932660702 @default.
- W171848939 hasRelatedWork W2972030141 @default.
- W171848939 hasRelatedWork W2983065389 @default.
- W171848939 hasRelatedWork W3045890682 @default.
- W171848939 hasRelatedWork W3048621119 @default.
- W171848939 hasRelatedWork W3176064562 @default.
- W171848939 hasRelatedWork W3176872475 @default.
- W171848939 hasRelatedWork W2154824098 @default.
- W171848939 isParatext "false" @default.
- W171848939 isRetracted "false" @default.
- W171848939 magId "171848939" @default.
- W171848939 workType "article" @default.