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- W1718607500 endingPage "51" @default.
- W1718607500 startingPage "1" @default.
- W1718607500 abstract "Abstract Xenobiotic transporters are required evaluated by the European and US regulatory agencies for the substrate and inhibition potential of drug candidates, due to the contribution of these to drug‐drug interactions. Interactions involving membrane transporters can alter the blood concentration time profiles of drugs, leading to altered levels of co‐administered drugs. Transporters play a role in toxicities, as inhibition of transporter activity could lead to increased drug concentrations or inhibition clearance of endogenous and exogenous substrates. While the SLC transporter family includes over 300 membrane bound transporters, less than 20 of these are currently considered relevant to drug related interactions. Of these, just eight are recommended by the regulatory agencies ‐ the ABC efflux transporters P‐gp and BCRP and the SLC uptake transporters OATP1B1, OATP1B3, OCT1 and BSEP which are hepatic, and the renal transporters OAT1, OAT3 and OCT2. This chapter discusses the major families of the SLC transporters that are involved in drug transport and provide information on structures, activities, substrates, inhibitors and genetic polymorphisms. Different in vitro and in vivo preclinical models are also discussed, so as to provide a more holistic view of these studies." @default.
- W1718607500 created "2016-06-24" @default.
- W1718607500 creator A5010578106 @default.
- W1718607500 creator A5058112913 @default.
- W1718607500 creator A5089791856 @default.
- W1718607500 date "2012-10-15" @default.
- W1718607500 modified "2023-10-12" @default.
- W1718607500 title "Solute Carrier (SLC) Family Transporters" @default.
- W1718607500 cites W1484689544 @default.
- W1718607500 cites W1486126828 @default.
- W1718607500 cites W1528647023 @default.
- W1718607500 cites W1558276030 @default.
- W1718607500 cites W1588849194 @default.
- W1718607500 cites W1604547439 @default.
- W1718607500 cites W170029080 @default.
- W1718607500 cites W1786528573 @default.
- W1718607500 cites W1788032165 @default.
- W1718607500 cites W1836899377 @default.
- W1718607500 cites W1964035404 @default.
- W1718607500 cites W1964471078 @default.
- W1718607500 cites W1965477067 @default.
- W1718607500 cites W1969949427 @default.
- W1718607500 cites W1970263371 @default.
- W1718607500 cites W1971901938 @default.
- W1718607500 cites W1974574813 @default.
- W1718607500 cites W1977244805 @default.
- W1718607500 cites W1977260692 @default.
- W1718607500 cites W1978017146 @default.
- W1718607500 cites W1979536626 @default.
- W1718607500 cites W1986732006 @default.
- W1718607500 cites W1988392474 @default.
- W1718607500 cites W1989696317 @default.
- W1718607500 cites W1989818377 @default.
- W1718607500 cites W1992094709 @default.
- W1718607500 cites W1992237854 @default.
- W1718607500 cites W1992653391 @default.
- W1718607500 cites W1992918939 @default.
- W1718607500 cites W1993198959 @default.
- W1718607500 cites W1994163115 @default.
- W1718607500 cites W1995297514 @default.
- W1718607500 cites W1995500412 @default.
- W1718607500 cites W1996100650 @default.
- W1718607500 cites W1997349791 @default.
- W1718607500 cites W1999617569 @default.
- W1718607500 cites W2000753827 @default.
- W1718607500 cites W2002867712 @default.
- W1718607500 cites W2003350833 @default.
- W1718607500 cites W2004361541 @default.
- W1718607500 cites W2004785370 @default.
- W1718607500 cites W2005518854 @default.
- W1718607500 cites W2007052092 @default.
- W1718607500 cites W2007989349 @default.
- W1718607500 cites W2008077160 @default.
- W1718607500 cites W2008607236 @default.
- W1718607500 cites W2008967210 @default.
- W1718607500 cites W2009222289 @default.
- W1718607500 cites W2012792624 @default.
- W1718607500 cites W2012910839 @default.
- W1718607500 cites W2013136764 @default.
- W1718607500 cites W2013793754 @default.
- W1718607500 cites W2014283537 @default.
- W1718607500 cites W2015755153 @default.
- W1718607500 cites W2018126221 @default.
- W1718607500 cites W2018424786 @default.
- W1718607500 cites W2020370268 @default.
- W1718607500 cites W2022073300 @default.
- W1718607500 cites W2022186415 @default.
- W1718607500 cites W2022713088 @default.
- W1718607500 cites W2022868074 @default.
- W1718607500 cites W2024587809 @default.
- W1718607500 cites W2026514323 @default.
- W1718607500 cites W2027014552 @default.
- W1718607500 cites W2027579967 @default.
- W1718607500 cites W2027788953 @default.
- W1718607500 cites W2028615902 @default.
- W1718607500 cites W2028890879 @default.
- W1718607500 cites W2031595392 @default.
- W1718607500 cites W2031861312 @default.
- W1718607500 cites W2031889365 @default.
- W1718607500 cites W2032960947 @default.
- W1718607500 cites W2033830119 @default.
- W1718607500 cites W2034886511 @default.
- W1718607500 cites W2034947261 @default.
- W1718607500 cites W2035090455 @default.
- W1718607500 cites W2037945577 @default.
- W1718607500 cites W2037983445 @default.
- W1718607500 cites W2041063533 @default.
- W1718607500 cites W2043590706 @default.
- W1718607500 cites W2045025729 @default.
- W1718607500 cites W2045266358 @default.
- W1718607500 cites W2046827775 @default.
- W1718607500 cites W2047099953 @default.
- W1718607500 cites W2047306923 @default.
- W1718607500 cites W2048521506 @default.
- W1718607500 cites W2048541050 @default.
- W1718607500 cites W2048593300 @default.
- W1718607500 cites W2048929758 @default.
- W1718607500 cites W2049390540 @default.