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• W1719209231 abstract "Publisher Summary This chapter summarizes the recent information about transcriptional regulation of the mouse thymidine kinase (TK) gene and the roles played by in this process cyclin/cyclin-dependent kinases (cdks), growth suppressor proteins, and transcription factors. The growth-factor-mediated signals that drive the cell-cycle progression and thereby cell proliferation have been linked recently to functions of cyclins, the regulatory subunits of cdks. Evidence has now accumulated to show that the G1/S phase-specific cyclin/cdk kinases modulate one or more transcription factors that in turn up-regulate transcription of several S phase genes, such as TK, shortly before initiation of DNA synthesis. Cyclins were first identified in marine invertebrate embryos as proteins that accumulate during interphase but undergo an abrupt degradation at the end of each mitosis. At the onset of S phase, expression of several genes encoding products associated with DNA replication are induced, including histones, TK, thymidylate synthase, and dihydrofolate reductase. TK is regulated at levels of transcription, post-transcription, translation, and post-translation, thus ensuring a large increase in its activity when cells enter S phase." @default.
• W1719209231 created "2016-06-24" @default.
• W1719209231 creator A5002769265 @default.
• W1719209231 creator A5051071198 @default.
• W1719209231 date "1996-01-01" @default.
• W1719209231 modified "2023-10-16" @default.
• W1719209231 title "Transcriptional Activation of Thymidine Kinase, a Marker for Cell Cycle Control" @default.
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• W1719209231 doi "https://doi.org/10.1016/s0079-6603(08)60145-2" @default.
• W1719209231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8650303" @default.
• W1719209231 hasPublicationYear "1996" @default.
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