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- W1719274191 abstract "Fruits of mulberry ( Morus alba) have been widely used for therapeutic purposes in Asian countries for centuries. Treatment of 3T3-L1 cells with ethanolic extracts of M. alba decreased adipocyte differentiation at 100 μg/mL by 18.6%. Treatment suppressed mRNA levels of PPARγ and C/EBPα expression in 3T3-L1 cells. However, the extract did not change free glycerol release from mature adipocytes. Thus, M. alba inhibited lipid accumulation by regulating transcription factors in 3T3-L1 adipocytes without a lipolytic effect. Among the soluble- fractions, the ethyl acetate-soluble fraction had the highest anti-adipogenic effects on 3T3-L1 cells. This fraction decreasing intracellular lipid accumulation by 38.5% in response to treatment with 100 μg/mL. In addition, HPLC analysis of the ethyl acetate-soluble fraction of M. alba contained 167.7 μM of protocatechulic acid in 1 mg/mL of fraction, which inhibited lipid accumulation by 44.8% in response to treatment with 100 μM. From these results, M. alba is a possible candidate for regulating lipid accumulation in obesity." @default.
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- W1719274191 date "2013-11-01" @default.
- W1719274191 modified "2023-09-25" @default.
- W1719274191 title "Inhibitory Effects of Ethyl Acetate-Soluble Fraction from Morus alba on Lipid Accumulation in 3T3-L1 Cells" @default.
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- W1719274191 doi "https://doi.org/10.1177/1934578x1300801120" @default.
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