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• W171936907 abstract "Research Article1 January 1993free access Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. I. Hoffmann I. Hoffmann Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author P.R. Clarke P.R. Clarke Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author M.J. Marcote M.J. Marcote Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author E. Karsenti E. Karsenti Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author G. Draetta G. Draetta Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author I. Hoffmann I. Hoffmann Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author P.R. Clarke P.R. Clarke Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author M.J. Marcote M.J. Marcote Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author E. Karsenti E. Karsenti Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author G. Draetta G. Draetta Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author Author Information I. Hoffmann1, P.R. Clarke1, M.J. Marcote1, E. Karsenti1 and G. Draetta1 1Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany. The EMBO Journal (1993)12:53-63https://doi.org/10.1002/j.1460-2075.1993.tb05631.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We have investigated the mechanisms responsible for the sudden activation of the cdc2-cyclin B protein kinase before mitosis. It has been found previously that cdc25 is the tyrosine phosphatase responsible for dephosphorylating and activating cdc2-cyclin B. In Xenopus eggs and early embryos a cdc25 homologue undergoes periodic phosphorylation and activation. Here we show that the catalytic activity of human cdc25-C phosphatase is also activated directly by phosphorylation in mitotic cells. Phosphorylation of cdc25-C in mitotic HeLa extracts or by cdc2-cyclin B increases its catalytic activity. cdc25-C is not a substrate of the cyclin A-associated kinases. cdc25-C is able to activate cdc2-cyclin B1 in Xenopus egg extracts and to induce Xenopus oocyte maturation, but only after stable thiophosphorylation. This demonstrates that phosphorylation of cdc25-C is required for the activation of cdc2-cyclin B and entry into M-phase. Together, these studies offer a plausible explanation for the rapid activation of cdc2-cyclin B at the onset of mitosis and the self-amplification of MPF observed in vivo. Previous ArticleNext Article Volume 12Issue 11 January 1993In this issue RelatedDetailsLoading ..." @default.
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• W171936907 date "1993-01-01" @default.
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• W171936907 title "Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis." @default.
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• W171936907 doi "https://doi.org/10.1002/j.1460-2075.1993.tb05631.x" @default.
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