Matches in SemOpenAlex for { <https://semopenalex.org/work/W1720186552> ?p ?o ?g. }
- W1720186552 endingPage "6293" @default.
- W1720186552 startingPage "6286" @default.
- W1720186552 abstract "Abstract Allergic asthma is associated with a pulmonary recruitment of Th type 2 cells, basophils, and eosinophils, mainly linked to chemokine production. CCL18 is a chemokine preferentially expressed in the lung, secreted by APCs, induced by Th2-type cytokines, and only present in humans. Therefore, CCL18 may be involved in allergic asthma. PBMC from asthmatics allergic to house dust mite cultured in the presence of Dermatophagoides pteronyssinus 1 (Der p 1) allergen secreted CCL18, 48 and 72 h after stimulation, whereas those from healthy donors did not. Part of CCL18 was directly derived from Der p 1-stimulated plasmacytoid dendritic cells, whereas the other part was linked to monocyte activation by IL-4 and IL-13 produced by Der p 1-stimulated T cells. In bronchoalveolar lavages from untreated asthmatic allergic patients, CCL18 was highly increased compared with controls. Functionally, CCL18 preferentially attracted in vitro-polarized Th2 cells and basophils, but not eosinophils and Th1 cells, and induced basophil histamine and intracellular calcium release. These data show a new function for CCL18, i.e., the recruitment of Th2 cells and basophils, and suggest that CCL18 may play a predominant role in allergic asthma." @default.
- W1720186552 created "2016-06-24" @default.
- W1720186552 creator A5003191308 @default.
- W1720186552 creator A5021234055 @default.
- W1720186552 creator A5024052748 @default.
- W1720186552 creator A5025900833 @default.
- W1720186552 creator A5044374733 @default.
- W1720186552 creator A5051650691 @default.
- W1720186552 creator A5058455342 @default.
- W1720186552 creator A5067276369 @default.
- W1720186552 creator A5068240990 @default.
- W1720186552 creator A5069011244 @default.
- W1720186552 creator A5071789258 @default.
- W1720186552 creator A5073870313 @default.
- W1720186552 creator A5087303813 @default.
- W1720186552 date "2006-05-15" @default.
- W1720186552 modified "2023-10-18" @default.
- W1720186552 title "Involvement of CCL18 in Allergic Asthma" @default.
- W1720186552 cites W1570067081 @default.
- W1720186552 cites W1582419036 @default.
- W1720186552 cites W1603447537 @default.
- W1720186552 cites W1671402728 @default.
- W1720186552 cites W1680121818 @default.
- W1720186552 cites W1870442784 @default.
- W1720186552 cites W1918895486 @default.
- W1720186552 cites W1919579956 @default.
- W1720186552 cites W1924532031 @default.
- W1720186552 cites W1963895131 @default.
- W1720186552 cites W1968813912 @default.
- W1720186552 cites W1970648068 @default.
- W1720186552 cites W1976041595 @default.
- W1720186552 cites W1980325904 @default.
- W1720186552 cites W1986991315 @default.
- W1720186552 cites W1997256321 @default.
- W1720186552 cites W1998605540 @default.
- W1720186552 cites W2000350636 @default.
- W1720186552 cites W2006285640 @default.
- W1720186552 cites W2006535217 @default.
- W1720186552 cites W2009563128 @default.
- W1720186552 cites W2012182755 @default.
- W1720186552 cites W2019948813 @default.
- W1720186552 cites W2042383304 @default.
- W1720186552 cites W2055522050 @default.
- W1720186552 cites W2055526040 @default.
- W1720186552 cites W2061114129 @default.
- W1720186552 cites W2062729668 @default.
- W1720186552 cites W2076347557 @default.
- W1720186552 cites W2080285248 @default.
- W1720186552 cites W2091101214 @default.
- W1720186552 cites W2099938481 @default.
- W1720186552 cites W2103384599 @default.
- W1720186552 cites W2112002503 @default.
- W1720186552 cites W2117339237 @default.
- W1720186552 cites W2130614990 @default.
- W1720186552 cites W2132309227 @default.
- W1720186552 cites W2152381037 @default.
- W1720186552 cites W2158722408 @default.
- W1720186552 cites W2163840855 @default.
- W1720186552 cites W2166982025 @default.
- W1720186552 cites W27497758 @default.
- W1720186552 cites W4243356479 @default.
- W1720186552 cites W4251037964 @default.
- W1720186552 cites W4313333678 @default.
- W1720186552 doi "https://doi.org/10.4049/jimmunol.176.10.6286" @default.
- W1720186552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16670340" @default.
- W1720186552 hasPublicationYear "2006" @default.
- W1720186552 type Work @default.
- W1720186552 sameAs 1720186552 @default.
- W1720186552 citedByCount "81" @default.
- W1720186552 countsByYear W17201865522012 @default.
- W1720186552 countsByYear W17201865522013 @default.
- W1720186552 countsByYear W17201865522014 @default.
- W1720186552 countsByYear W17201865522015 @default.
- W1720186552 countsByYear W17201865522016 @default.
- W1720186552 countsByYear W17201865522017 @default.
- W1720186552 countsByYear W17201865522018 @default.
- W1720186552 countsByYear W17201865522019 @default.
- W1720186552 countsByYear W17201865522020 @default.
- W1720186552 countsByYear W17201865522021 @default.
- W1720186552 countsByYear W17201865522022 @default.
- W1720186552 countsByYear W17201865522023 @default.
- W1720186552 crossrefType "journal-article" @default.
- W1720186552 hasAuthorship W1720186552A5003191308 @default.
- W1720186552 hasAuthorship W1720186552A5021234055 @default.
- W1720186552 hasAuthorship W1720186552A5024052748 @default.
- W1720186552 hasAuthorship W1720186552A5025900833 @default.
- W1720186552 hasAuthorship W1720186552A5044374733 @default.
- W1720186552 hasAuthorship W1720186552A5051650691 @default.
- W1720186552 hasAuthorship W1720186552A5058455342 @default.
- W1720186552 hasAuthorship W1720186552A5067276369 @default.
- W1720186552 hasAuthorship W1720186552A5068240990 @default.
- W1720186552 hasAuthorship W1720186552A5069011244 @default.
- W1720186552 hasAuthorship W1720186552A5071789258 @default.
- W1720186552 hasAuthorship W1720186552A5073870313 @default.
- W1720186552 hasAuthorship W1720186552A5087303813 @default.
- W1720186552 hasBestOaLocation W17201865521 @default.
- W1720186552 hasConcept C126322002 @default.
- W1720186552 hasConcept C13373296 @default.