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- W1720199953 abstract "Abstract Stem cells from a lpr/lpr mouse do not cause the lpr syndrome characteristic of unmanipulated MRL/lpr mice when injected into nonautoimmune neonatal mice. Instead, these neonatal chimeras gradually become markedly lymphopenic. As adults, only limited donor cell engraftment (approximately 5%) was evident as assessed by cell surface staining of H-2D or Thy-1 allelic markers. However, the relatively low number of lpr/lpr-derived B cells produced greater than 90% of the circulating IgG2a antibody and all detectable IgG2a anti-ssDNA autoantibody, indicating that lpr/lpr B cells express an intrinsic genetic defect resulting in hyper-IgG and autoantibody secretion." @default.
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- W1720199953 date "1990-07-15" @default.
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- W1720199953 title "Evidence for an intrinsic B cell defect in lpr/lpr mice apparent in neonatal chimeras." @default.
- W1720199953 doi "https://doi.org/10.4049/jimmunol.145.2.549" @default.
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