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- W172249922 abstract "Most of the calcium in the body resides in the bones as mineralized matrix. Bone has three major types of cells: osteoblasts cover the bone and lay down the organic matrix that forms bone; osteocytes reside in lacunae and communicate via canaliculi; giant multinucleated osteoclasts resorb bone mineral and matrix in a reaction akin to inflammation. The number and activity of these cells determines bone balance. Calcitonin inhibits osteolysis by the osteoclasts. Parathyroid hormone (PTH) recruits stem cells in the blood to become osteoclasts, through receptors on the osteoblasts. PTH and vitamin D both stimulate macrophage colony stimulating factor production by the osteoblasts that recruit cells from the plasma to bind to osteoblasts to form osteoclasts. PTH decreases Ca and phosphate reabsorption from the ultrafiltrate in the proximal tubule but increases reabsorption of Ca from the distal nephron. Vitamin D stimulates both Ca and phosphate reabsorption from the distal nephron. Vitamin is the only hormone that affects the intestine to make it absorb Ca and phosphate more avidly." @default.
- W172249922 created "2016-06-24" @default.
- W172249922 creator A5002162344 @default.
- W172249922 date "2017-01-01" @default.
- W172249922 modified "2023-10-11" @default.
- W172249922 title "Calcium and Phosphorus Homeostasis II" @default.
- W172249922 doi "https://doi.org/10.1016/b978-0-12-800883-6.00091-4" @default.
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