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• W1723187988 abstract "Research Article1 March 1992free access Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. P.S. Danielian P.S. Danielian Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author R. White R. White Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author J.A. Lees J.A. Lees Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author M.G. Parker M.G. Parker Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author P.S. Danielian P.S. Danielian Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author R. White R. White Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author J.A. Lees J.A. Lees Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author M.G. Parker M.G. Parker Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. Search for more papers by this author Author Information P.S. Danielian1, R. White1, J.A. Lees1 and M.G. Parker1 1Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK. The EMBO Journal (1992)11:1025-1033https://doi.org/10.1002/j.1460-2075.1992.tb05141.x Correction(s) for this article Erratum01 June 1992 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The oestrogen receptor stimulates transcription by means of at least two distinct transcriptional activation domains, TAF-1 in the N-terminal domain and TAF-2 in the hormone binding domain. Here we show that TAF-2 activity requires a region in the C-terminus of the hormone binding domain between residues 538 and 552 in the mouse oestrogen receptor which is conserved among many nuclear hormone receptors. Point mutagenesis of conserved hydrophobic and charged residues significantly reduced ligand dependent transcriptional activation but had no effect on steroid or DNA binding. Mutation of the corresponding residues in the glucocorticoid receptor also abolished transcriptional activation. We therefore propose that the conserved region may be essential for ligand dependent transcriptional activation by other members of the nuclear receptor family. Previous ArticleNext Article Volume 11Issue 31 March 1992In this issue RelatedDetailsLoading ..." @default.
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• W1723187988 date "1992-03-01" @default.
• W1723187988 modified "2023-10-11" @default.
• W1723187988 title "Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors." @default.
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• W1723187988 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05141.x" @default.
• W1723187988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/556543" @default.
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• W1723187988 hasPublicationYear "1992" @default.
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