FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1723331330> ?p ?o ?g. }

• W1723331330 endingPage "2295" @default.
• W1723331330 startingPage "2290" @default.
• W1723331330 abstract "SummaryObjective: The role of vitronectin (VN) in thrombosis is not fully understood, primarily because this adhesive glycoprotein not only stabilizes plasminogen activator inhibitor 1 (PAI-1) and thus protects fibrin from premature lysis, but also because it binds to platelet integrins and may influence platelet aggregation. The absence of quantitative approaches to characterize the thrombi formed in animal models under different conditions further complicates this analysis. Methods: In this report, we describe a more comprehensive approach to assess the stability of thrombi formed in mice deficient in PAI-1 (PAI-1−/−), VN (VN−/−) or both (PAI-1−/−/VN−/−). Results: We observed that all deficient mice developed unstable thrombi compared with wild type (WT) mice. Thus, only 31% of the thrombi formed in WT mice were unstable compared with 74% of PAI-1−/−, 80% of VN−/−, and 87% of PAI-1−/−/VN−/− mice. In this regard, the average number of emboli per WT mouse was significantly lower (0.55) compared with VN−/− (2.66), PAI-1−/− (2.1), and VN−/−/PAI-1−/− (2.35) mice. Finally, the total duration of complete vascular occlusion was higher and the rate of vascular patency was lower in the WT mice compared with the deficient mice. Conclusions: Taken together, these observations indicate that the thrombotic phenotype of mice with a combined deficiency in PAI-1 and VN does not differ significantly from the phenotype of mice with deficiencies in only PAI-1 or VN. This observation suggests that PAI-1 and VN may influence thrombus stability by regulating a common pathway. Objective: The role of vitronectin (VN) in thrombosis is not fully understood, primarily because this adhesive glycoprotein not only stabilizes plasminogen activator inhibitor 1 (PAI-1) and thus protects fibrin from premature lysis, but also because it binds to platelet integrins and may influence platelet aggregation. The absence of quantitative approaches to characterize the thrombi formed in animal models under different conditions further complicates this analysis. Methods: In this report, we describe a more comprehensive approach to assess the stability of thrombi formed in mice deficient in PAI-1 (PAI-1−/−), VN (VN−/−) or both (PAI-1−/−/VN−/−). Results: We observed that all deficient mice developed unstable thrombi compared with wild type (WT) mice. Thus, only 31% of the thrombi formed in WT mice were unstable compared with 74% of PAI-1−/−, 80% of VN−/−, and 87% of PAI-1−/−/VN−/− mice. In this regard, the average number of emboli per WT mouse was significantly lower (0.55) compared with VN−/− (2.66), PAI-1−/− (2.1), and VN−/−/PAI-1−/− (2.35) mice. Finally, the total duration of complete vascular occlusion was higher and the rate of vascular patency was lower in the WT mice compared with the deficient mice. Conclusions: Taken together, these observations indicate that the thrombotic phenotype of mice with a combined deficiency in PAI-1 and VN does not differ significantly from the phenotype of mice with deficiencies in only PAI-1 or VN. This observation suggests that PAI-1 and VN may influence thrombus stability by regulating a common pathway." @default.
• W1723331330 created "2016-06-24" @default.
• W1723331330 creator A5006325041 @default.
• W1723331330 creator A5042248757 @default.
• W1723331330 creator A5052410552 @default.
• W1723331330 creator A5058755333 @default.
• W1723331330 creator A5077803529 @default.
• W1723331330 date "2005-10-01" @default.
• W1723331330 modified "2023-10-11" @default.
• W1723331330 title "Thrombotic phenotype of mice with a combined deficiency in plasminogen activator inhibitor 1 and vitronectin" @default.
• W1723331330 cites W1493779021 @default.
• W1723331330 cites W1562197596 @default.
• W1723331330 cites W1579151760 @default.
• W1723331330 cites W1589957034 @default.
• W1723331330 cites W1965723799 @default.
• W1723331330 cites W1972292328 @default.
• W1723331330 cites W1986292788 @default.
• W1723331330 cites W1986612369 @default.
• W1723331330 cites W2000312990 @default.
• W1723331330 cites W2005185823 @default.
• W1723331330 cites W2008241123 @default.
• W1723331330 cites W2008735759 @default.
• W1723331330 cites W2032102036 @default.
• W1723331330 cites W2039831544 @default.
• W1723331330 cites W2047131018 @default.
• W1723331330 cites W2051958715 @default.
• W1723331330 cites W2062969878 @default.
• W1723331330 cites W2068005229 @default.
• W1723331330 cites W2074672488 @default.
• W1723331330 cites W2091711142 @default.
• W1723331330 cites W2104777086 @default.
• W1723331330 cites W2105114389 @default.
• W1723331330 cites W2124245160 @default.
• W1723331330 cites W2139195153 @default.
• W1723331330 cites W216931071 @default.
• W1723331330 cites W2345436650 @default.
• W1723331330 cites W4239481903 @default.
• W1723331330 doi "https://doi.org/10.1111/j.1538-7836.2005.01479.x" @default.
• W1723331330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16194205" @default.
• W1723331330 hasPublicationYear "2005" @default.
• W1723331330 type Work @default.
• W1723331330 sameAs 1723331330 @default.
• W1723331330 citedByCount "16" @default.
• W1723331330 countsByYear W17233313302012 @default.
• W1723331330 countsByYear W17233313302013 @default.
• W1723331330 countsByYear W17233313302015 @default.
• W1723331330 countsByYear W17233313302018 @default.
• W1723331330 countsByYear W17233313302021 @default.
• W1723331330 countsByYear W17233313302023 @default.
• W1723331330 crossrefType "journal-article" @default.
• W1723331330 hasAuthorship W1723331330A5006325041 @default.
• W1723331330 hasAuthorship W1723331330A5042248757 @default.
• W1723331330 hasAuthorship W1723331330A5052410552 @default.
• W1723331330 hasAuthorship W1723331330A5058755333 @default.
• W1723331330 hasAuthorship W1723331330A5077803529 @default.
• W1723331330 hasBestOaLocation W17233313301 @default.
• W1723331330 hasConcept C104317684 @default.
• W1723331330 hasConcept C126322002 @default.
• W1723331330 hasConcept C127716648 @default.
• W1723331330 hasConcept C134018914 @default.
• W1723331330 hasConcept C164144092 @default.
• W1723331330 hasConcept C170493617 @default.
• W1723331330 hasConcept C185592680 @default.
• W1723331330 hasConcept C195687474 @default.
• W1723331330 hasConcept C203014093 @default.
• W1723331330 hasConcept C2776825266 @default.
• W1723331330 hasConcept C2779679481 @default.
• W1723331330 hasConcept C2780675426 @default.
• W1723331330 hasConcept C2780868729 @default.
• W1723331330 hasConcept C2781362458 @default.
• W1723331330 hasConcept C54173615 @default.
• W1723331330 hasConcept C55493867 @default.
• W1723331330 hasConcept C71924100 @default.
• W1723331330 hasConcept C89560881 @default.
• W1723331330 hasConceptScore W1723331330C104317684 @default.
• W1723331330 hasConceptScore W1723331330C126322002 @default.
• W1723331330 hasConceptScore W1723331330C127716648 @default.
• W1723331330 hasConceptScore W1723331330C134018914 @default.
• W1723331330 hasConceptScore W1723331330C164144092 @default.
• W1723331330 hasConceptScore W1723331330C170493617 @default.
• W1723331330 hasConceptScore W1723331330C185592680 @default.
• W1723331330 hasConceptScore W1723331330C195687474 @default.
• W1723331330 hasConceptScore W1723331330C203014093 @default.
• W1723331330 hasConceptScore W1723331330C2776825266 @default.
• W1723331330 hasConceptScore W1723331330C2779679481 @default.
• W1723331330 hasConceptScore W1723331330C2780675426 @default.
• W1723331330 hasConceptScore W1723331330C2780868729 @default.
• W1723331330 hasConceptScore W1723331330C2781362458 @default.
• W1723331330 hasConceptScore W1723331330C54173615 @default.
• W1723331330 hasConceptScore W1723331330C55493867 @default.
• W1723331330 hasConceptScore W1723331330C71924100 @default.
• W1723331330 hasConceptScore W1723331330C89560881 @default.
• W1723331330 hasIssue "10" @default.
• W1723331330 hasLocation W17233313301 @default.
• W1723331330 hasLocation W17233313302 @default.
• W1723331330 hasOpenAccess W1723331330 @default.
• W1723331330 hasPrimaryLocation W17233313301 @default.
• W1723331330 hasRelatedWork W1991243300 @default.

• next