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- W172337408 abstract "Induction of immunological tolerance via anergic or regulatory T cells is a potential therapeutic strategy for immunological diseases such as allergy and autoimmunity. Despite extensive investigation into the mechanism of anergic and regulatory T cell-mediated immune suppression, the exact mechanism is still unclear. This project investigated the migration characteristics of anergic and regulatory T cells, in comparison to conventional T cells, by using a parallel-plate flow chamber assay and ova albumin (OVA)-TCR transgenic DO11.10 mice. Anergic T cells were generated by treating DO11.10 splenocytes with anti-CD80, anti-CD86 and anti-ICOSL blocking Abs before stimulation by OVA. On flowing through ICAM-1 and E-selectin at shear stress of 1.5 dynes/cm2, anergic T cells exhibited a significant reduction of adhesion as compared to OVA-stimulated effector T cells (71% reduction, P<0.001). In the same flow chamber system, activated CD4+CD25+ regulatory T cells isolated from DO11.10 mice also showed a significantly decreased adhesion compared to CD4+CD25− T cells (76% reduction, P<0.001). Reduced adhesion of the suppressor cells was also observed when using an endothelial cell-based flow chamber system. These findings demonstrate differential migration phenotypes of suppressor and effector T cells, suggesting distinct migration property may contribute to the execution of individual immune function. Funded by the Taiwan National Science Council and National Taiwan University Hospital" @default.
- W172337408 created "2016-06-24" @default.
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- W172337408 date "2007-01-01" @default.
- W172337408 modified "2023-09-24" @default.
- W172337408 title "Suppressor and effector T cells exhibit differential migration capacity" @default.
- W172337408 doi "https://doi.org/10.1096/fasebj.21.6.a773-c" @default.
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