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- W172357417 abstract "SummaryThree children, suffering from SCID, were lacking a genotypically identical sibling. One of them demonstrated spontaneous graft-versus-host (GvH) reaction due to a maternofetal transfusion. They were transplanted with the marrow of the HLA-A-mismatched but otherwise identical mother (1), with that of the completely mismatched mother in the case of spontaneous GvH (2) and with cultivated thymus epithelium (3). Full (twice) or partial (once) immunore-constitution was achieved. Total bone marrow or myeloid suppression was seen in all three cases, as well as autoimmune hemolytic anemia in one case.In the patient who received thymus epithelium, engraftment of donor derived T-cells was detected. Further maturation of the host’s own B-cells was observed and a certain amount of cooperation developed between the completely HLA-mismatched donor derived T-cells and the host’s B-cells." @default.
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- W172357417 date "1980-01-01" @default.
- W172357417 modified "2023-10-18" @default.
- W172357417 title "Split Chimerism in Three Patients Suffering from Severe Combined Immunodeficiency (SCID)" @default.
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- W172357417 doi "https://doi.org/10.1007/978-3-642-67319-1_34" @default.
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