FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1723772693> ?p ?o ?g. }

• W1723772693 endingPage "1703" @default.
• W1723772693 startingPage "1692" @default.
• W1723772693 abstract "Untreated and minimally pretreated solid tumor patients received alternating sequences of taxol and cisplatin. Sequential dose escalation of each agent using taxol doses of 110 or 135 mg/m2 and cisplatin doses of 50 or 75 mg/m2 resulted in four dosage permutations that induced grades 3 and 4 neutropenia in 72% to 84% and 50% to 53% of courses, respectively. Neutropenia was brief, and hospitalization for neutropenia and fever was required in 13% to 24% of courses. However, further escalation of taxol to 170 or 200 mg/m2 induced grade 4 neutropenia in 79% to 82% of courses. At the highest taxol-cisplatin dose level (200 mg/m2 to 75 mg/m2), the mean neutrophil count nadir was 98/microL, and hospitalization for neutropenia and fever was required in 64% of courses. The sequence of cisplatin before taxol, which has less antitumor activity in vitro, induced more profound neutropenia than the alternate sequence. Pharmacologic studies indicated that this difference was probably due to 25% lower taxol clearance rates when cisplatin preceded taxol. Although neurotoxicity was initially thought to be a potentially serious effect of the combination, mild to modest neurotoxicity occurred in only 27% of patients. Adverse effects also included myalgias, alopecia, vomiting, diarrhea, bradycardia, and asymptomatic ventricular tachycardia. Objective responses were noted in melanoma, as well as non-small-cell lung, ovarian, breast, head and neck, colon, and pancreatic carcinomas. Based on these results, the sequence of taxol before cisplatin at doses of 135 and 75 mg/m2, respectively, is recommended for phase II/III trials, with escalation of taxol to 170 mg/m2 if treatment is well tolerated." @default.
• W1723772693 created "2016-06-24" @default.
• W1723772693 creator A5002365746 @default.
• W1723772693 creator A5003214440 @default.
• W1723772693 creator A5003528816 @default.
• W1723772693 creator A5011905014 @default.
• W1723772693 creator A5019357584 @default.
• W1723772693 creator A5032256344 @default.
• W1723772693 creator A5034392417 @default.
• W1723772693 creator A5041155600 @default.
• W1723772693 creator A5061258186 @default.
• W1723772693 creator A5064627876 @default.
• W1723772693 date "1991-09-01" @default.
• W1723772693 modified "2023-10-14" @default.
• W1723772693 title "Sequences of taxol and cisplatin: a phase I and pharmacologic study." @default.
• W1723772693 cites W125538458 @default.
• W1723772693 cites W1779739875 @default.
• W1723772693 cites W1935541780 @default.
• W1723772693 cites W1970797471 @default.
• W1723772693 cites W1981534406 @default.
• W1723772693 cites W2001222315 @default.
• W1723772693 cites W2058979413 @default.
• W1723772693 cites W2096102243 @default.
• W1723772693 cites W2143202928 @default.
• W1723772693 cites W2176435341 @default.
• W1723772693 cites W2471778735 @default.
• W1723772693 doi "https://doi.org/10.1200/jco.1991.9.9.1692" @default.
• W1723772693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1678780" @default.
• W1723772693 hasPublicationYear "1991" @default.
• W1723772693 type Work @default.
• W1723772693 sameAs 1723772693 @default.
• W1723772693 citedByCount "410" @default.
• W1723772693 countsByYear W17237726932012 @default.
• W1723772693 countsByYear W17237726932013 @default.
• W1723772693 countsByYear W17237726932014 @default.
• W1723772693 countsByYear W17237726932015 @default.
• W1723772693 countsByYear W17237726932016 @default.
• W1723772693 countsByYear W17237726932017 @default.
• W1723772693 countsByYear W17237726932018 @default.
• W1723772693 countsByYear W17237726932019 @default.
• W1723772693 countsByYear W17237726932020 @default.
• W1723772693 countsByYear W17237726932021 @default.
• W1723772693 countsByYear W17237726932022 @default.
• W1723772693 countsByYear W17237726932023 @default.
• W1723772693 crossrefType "journal-article" @default.
• W1723772693 hasAuthorship W1723772693A5002365746 @default.
• W1723772693 hasAuthorship W1723772693A5003214440 @default.
• W1723772693 hasAuthorship W1723772693A5003528816 @default.
• W1723772693 hasAuthorship W1723772693A5011905014 @default.
• W1723772693 hasAuthorship W1723772693A5019357584 @default.
• W1723772693 hasAuthorship W1723772693A5032256344 @default.
• W1723772693 hasAuthorship W1723772693A5034392417 @default.
• W1723772693 hasAuthorship W1723772693A5041155600 @default.
• W1723772693 hasAuthorship W1723772693A5061258186 @default.
• W1723772693 hasAuthorship W1723772693A5064627876 @default.
• W1723772693 hasConcept C126322002 @default.
• W1723772693 hasConcept C141071460 @default.
• W1723772693 hasConcept C197934379 @default.
• W1723772693 hasConcept C2776694085 @default.
• W1723772693 hasConcept C2777063308 @default.
• W1723772693 hasConcept C2777292972 @default.
• W1723772693 hasConcept C2778239845 @default.
• W1723772693 hasConcept C2780852908 @default.
• W1723772693 hasConcept C42219234 @default.
• W1723772693 hasConcept C71924100 @default.
• W1723772693 hasConcept C90924648 @default.
• W1723772693 hasConcept C98274493 @default.
• W1723772693 hasConceptScore W1723772693C126322002 @default.
• W1723772693 hasConceptScore W1723772693C141071460 @default.
• W1723772693 hasConceptScore W1723772693C197934379 @default.
• W1723772693 hasConceptScore W1723772693C2776694085 @default.
• W1723772693 hasConceptScore W1723772693C2777063308 @default.
• W1723772693 hasConceptScore W1723772693C2777292972 @default.
• W1723772693 hasConceptScore W1723772693C2778239845 @default.
• W1723772693 hasConceptScore W1723772693C2780852908 @default.
• W1723772693 hasConceptScore W1723772693C42219234 @default.
• W1723772693 hasConceptScore W1723772693C71924100 @default.
• W1723772693 hasConceptScore W1723772693C90924648 @default.
• W1723772693 hasConceptScore W1723772693C98274493 @default.
• W1723772693 hasIssue "9" @default.
• W1723772693 hasLocation W17237726931 @default.
• W1723772693 hasLocation W17237726932 @default.
• W1723772693 hasOpenAccess W1723772693 @default.
• W1723772693 hasPrimaryLocation W17237726931 @default.
• W1723772693 hasRelatedWork W1974008536 @default.
• W1723772693 hasRelatedWork W2061260524 @default.
• W1723772693 hasRelatedWork W2122995651 @default.
• W1723772693 hasRelatedWork W2347566873 @default.
• W1723772693 hasRelatedWork W2367636752 @default.
• W1723772693 hasRelatedWork W2380099415 @default.
• W1723772693 hasRelatedWork W2525932590 @default.
• W1723772693 hasRelatedWork W3032488393 @default.
• W1723772693 hasRelatedWork W3100395499 @default.
• W1723772693 hasRelatedWork W2118693777 @default.
• W1723772693 hasVolume "9" @default.
• W1723772693 isParatext "false" @default.
• W1723772693 isRetracted "false" @default.
• W1723772693 magId "1723772693" @default.

• next