FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1724297952> ?p ?o ?g. }

• W1724297952 endingPage "5867" @default.
• W1724297952 startingPage "5862" @default.
• W1724297952 abstract "In the vaccine strategy against HIV, bacillus Calmette-Guérin (BCG), a live attenuated strain of Mycobacterium bovis, is considered to be one of potential vectors for mucosal delivery of vaccine Ag. We analyzed the induction of the Ag-specific Ab response by nasal immunization with recombinant BCG vector-based vaccine (rBCG-V3J1) that can secrete the V3 principal neutralizing epitope of HIV. Mice were nasally immunized with rBCG-V3J1 (10 microg) three times at weekly intervals. Four weeks after the initial immunization, high titers of V3J1-specific IgG Abs were seen in serum. These high levels of HIV-specific serum IgG responses were maintained for >12 mo following nasal immunization without any booster immunization. V3J1-specific IgG-producing cells were detected in mononuclear cells isolated from spleen, nasal cavity, and salivary gland of the nasally vaccinated mice. Nasal rBCG-V3J1 also induced high levels of prolonged HIV-specific serum IgG responses in Th1 (IFN-gamma(-/-))- or Th2 (IL-4(-/-))-immunodeficient mice. Further, IgG3 was highest among V3 peptide-specific IgG subclass Ab responses in these immunodeficient mice as well as in wild-type mice. In addition, this Ag-specific serum IgG Abs induced by nasal immunization with rBCG-V3J1 possessed the ability to neutralize clinical isolate of HIV in vitro. These results suggested that the nasal rBCG-V3J1 system might be used as a therapeutic vaccine in addition to a prophylaxis vaccine for the control of AIDS." @default.
• W1724297952 created "2016-06-24" @default.
• W1724297952 creator A5005431176 @default.
• W1724297952 creator A5022602582 @default.
• W1724297952 creator A5044791422 @default.
• W1724297952 creator A5082923252 @default.
• W1724297952 creator A5086007605 @default.
• W1724297952 creator A5087178931 @default.
• W1724297952 creator A5089554474 @default.
• W1724297952 date "2001-11-15" @default.
• W1724297952 modified "2023-10-16" @default.
• W1724297952 title "HIV Mucosal Vaccine: Nasal Immunization with rBCG-V3J1 Induces a Long Term V3J1 Peptide-Specific Neutralizing Immunity in Th1- and Th2-Deficient Conditions" @default.
• W1724297952 cites W1578285344 @default.
• W1724297952 cites W1639090197 @default.
• W1724297952 cites W1822280446 @default.
• W1724297952 cites W1886464987 @default.
• W1724297952 cites W1940046231 @default.
• W1724297952 cites W1963958510 @default.
• W1724297952 cites W1975010250 @default.
• W1724297952 cites W1975568458 @default.
• W1724297952 cites W1975826225 @default.
• W1724297952 cites W1984811742 @default.
• W1724297952 cites W1988335886 @default.
• W1724297952 cites W1997050521 @default.
• W1724297952 cites W2007282352 @default.
• W1724297952 cites W2022760428 @default.
• W1724297952 cites W2023246295 @default.
• W1724297952 cites W2038256546 @default.
• W1724297952 cites W2039062794 @default.
• W1724297952 cites W2046010707 @default.
• W1724297952 cites W2049304208 @default.
• W1724297952 cites W2057410806 @default.
• W1724297952 cites W2067632663 @default.
• W1724297952 cites W2083033324 @default.
• W1724297952 cites W2094829985 @default.
• W1724297952 cites W2109720868 @default.
• W1724297952 cites W2113037681 @default.
• W1724297952 cites W2124445678 @default.
• W1724297952 cites W2133813477 @default.
• W1724297952 cites W2139605631 @default.
• W1724297952 cites W2147103967 @default.
• W1724297952 cites W2166883229 @default.
• W1724297952 cites W2320498484 @default.
• W1724297952 cites W2327503296 @default.
• W1724297952 cites W4313335045 @default.
• W1724297952 doi "https://doi.org/10.4049/jimmunol.167.10.5862" @default.
• W1724297952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11698461" @default.
• W1724297952 hasPublicationYear "2001" @default.
• W1724297952 type Work @default.
• W1724297952 sameAs 1724297952 @default.
• W1724297952 citedByCount "41" @default.
• W1724297952 countsByYear W17242979522012 @default.
• W1724297952 countsByYear W17242979522013 @default.
• W1724297952 countsByYear W17242979522015 @default.
• W1724297952 countsByYear W17242979522018 @default.
• W1724297952 crossrefType "journal-article" @default.
• W1724297952 hasAuthorship W1724297952A5005431176 @default.
• W1724297952 hasAuthorship W1724297952A5022602582 @default.
• W1724297952 hasAuthorship W1724297952A5044791422 @default.
• W1724297952 hasAuthorship W1724297952A5082923252 @default.
• W1724297952 hasAuthorship W1724297952A5086007605 @default.
• W1724297952 hasAuthorship W1724297952A5087178931 @default.
• W1724297952 hasAuthorship W1724297952A5089554474 @default.
• W1724297952 hasBestOaLocation W17242979521 @default.
• W1724297952 hasConcept C159047783 @default.
• W1724297952 hasConcept C159654299 @default.
• W1724297952 hasConcept C167508917 @default.
• W1724297952 hasConcept C195616568 @default.
• W1724297952 hasConcept C203014093 @default.
• W1724297952 hasConcept C22070199 @default.
• W1724297952 hasConcept C2776789287 @default.
• W1724297952 hasConcept C2777289321 @default.
• W1724297952 hasConcept C2778190748 @default.
• W1724297952 hasConcept C2779261636 @default.
• W1724297952 hasConcept C2780195530 @default.
• W1724297952 hasConcept C2780801004 @default.
• W1724297952 hasConcept C2780898057 @default.
• W1724297952 hasConcept C59377437 @default.
• W1724297952 hasConcept C71924100 @default.
• W1724297952 hasConcept C85663871 @default.
• W1724297952 hasConcept C86803240 @default.
• W1724297952 hasConcept C8891405 @default.
• W1724297952 hasConceptScore W1724297952C159047783 @default.
• W1724297952 hasConceptScore W1724297952C159654299 @default.
• W1724297952 hasConceptScore W1724297952C167508917 @default.
• W1724297952 hasConceptScore W1724297952C195616568 @default.
• W1724297952 hasConceptScore W1724297952C203014093 @default.
• W1724297952 hasConceptScore W1724297952C22070199 @default.
• W1724297952 hasConceptScore W1724297952C2776789287 @default.
• W1724297952 hasConceptScore W1724297952C2777289321 @default.
• W1724297952 hasConceptScore W1724297952C2778190748 @default.
• W1724297952 hasConceptScore W1724297952C2779261636 @default.
• W1724297952 hasConceptScore W1724297952C2780195530 @default.
• W1724297952 hasConceptScore W1724297952C2780801004 @default.
• W1724297952 hasConceptScore W1724297952C2780898057 @default.
• W1724297952 hasConceptScore W1724297952C59377437 @default.
• W1724297952 hasConceptScore W1724297952C71924100 @default.
• W1724297952 hasConceptScore W1724297952C85663871 @default.

• next