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- W172476547 abstract "In seasonal breeders such as the European roe deer (Capreolus capreolus) the well timed regulation of testicular functions is crucial to repro-ductive fitness and successful breeding. Such functions are in particular the production of spermatozoa and testosterone. Having only a very short rutting season from mid-July to mid-August, roe deer testis undergo drastic cyclic changes during the transitions between breeding and non-breeding seasons. These changes require mechanisms to stimulate both cell proliferation and spermatogenesis during testis growth (re-crudescence) and to initiate repression of spermatogenesis during testis involution. The expression of genes responsible for these local con-trol mechanisms needs to be seasonally regulated. Due to the lack of a fully sequenced roe deer genome, we used an 8K expression microar-ray from cattle as its evolutionary closest and sequenced relative to investigate the gene expression changes in roe deer testis during the tran-sition between the two extreme phases of the circannual testicular development: the arrest of spermatogenesis (December) on one hand and the fully activated spermatogenesis (June) on the other. During the transition from December to June, 622 genes were significantly differen-tially expressed (p < 0.05). Out of the 407 genes found to be up-regulated, 197 exhibited an increase in expression of twofold or more, and 132 out of the 215 down-regulated genes showed a decrease of twofold or more. Based on database queries, 51 of the differentially expressed genes could be assigned to 50 broad biological processes, 32 of which covered molecular functions and 28 were assigned to different cell components." @default.
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- W172476547 date "2010-11-14" @default.
- W172476547 modified "2023-09-26" @default.
- W172476547 title "Seasonal Changes of Gene Expression in Roe Deer (Capreolus Capreolus) Testis Measured by Expression Microarray Analysis" @default.
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