Matches in SemOpenAlex for { <https://semopenalex.org/work/W172511037> ?p ?o ?g. }
- W172511037 endingPage "522" @default.
- W172511037 startingPage "487" @default.
- W172511037 abstract "Pharmacological interference with sphingolipid metabolizing enzymes promises to provide novel ways to modulate cellular pathways relevant in multiple diseases. In this review, we focus on two sphingolipid signaling molecules, sphingosine-1-phosphate (S1P) and ceramide, as they are involved in cell fate decisions (survival vs. apoptosis) and in a wide range of pathophysiological processes. For S1P, we will discuss sphingosine kinases and S1P lyase as the enzymes which are crucial for its production and degradation, respectively, emphasizing the potential therapeutic usefulness of inhibitors of these enzymes. For ceramide, we will concentrate on acid sphingomyelinase, and critically review the substantial literature which implicates this enzyme as a worthwhile target for pharmacological inhibitors. It will become clear that the task to validate these enzymes as drug targets is not finished and many questions regarding the therapeutic usefulness of their inhibitors remain unanswered. Still this approach holds promise for a number of totally new therapies, and, on the way, detailed insight into sphingolipid signaling pathways can be gained." @default.
- W172511037 created "2016-06-24" @default.
- W172511037 creator A5038950669 @default.
- W172511037 creator A5048426910 @default.
- W172511037 date "2008-08-26" @default.
- W172511037 modified "2023-09-23" @default.
- W172511037 title "Sphingolipid Metabolizing Enzymes as Novel Therapeutic Targets" @default.
- W172511037 cites W1517647708 @default.
- W172511037 cites W1528964823 @default.
- W172511037 cites W1551881962 @default.
- W172511037 cites W1572221045 @default.
- W172511037 cites W1607948351 @default.
- W172511037 cites W1657392119 @default.
- W172511037 cites W1824709994 @default.
- W172511037 cites W1827287971 @default.
- W172511037 cites W1958507659 @default.
- W172511037 cites W1964455368 @default.
- W172511037 cites W1964520752 @default.
- W172511037 cites W1967640847 @default.
- W172511037 cites W1969996654 @default.
- W172511037 cites W1970911936 @default.
- W172511037 cites W1970977554 @default.
- W172511037 cites W1972686602 @default.
- W172511037 cites W1973573934 @default.
- W172511037 cites W1976709850 @default.
- W172511037 cites W1976811664 @default.
- W172511037 cites W1978193307 @default.
- W172511037 cites W1978227165 @default.
- W172511037 cites W1978465583 @default.
- W172511037 cites W1978707192 @default.
- W172511037 cites W1979998867 @default.
- W172511037 cites W1980782120 @default.
- W172511037 cites W1982965514 @default.
- W172511037 cites W1984482195 @default.
- W172511037 cites W1987620055 @default.
- W172511037 cites W1987711034 @default.
- W172511037 cites W1987835768 @default.
- W172511037 cites W1987839661 @default.
- W172511037 cites W1988712957 @default.
- W172511037 cites W1989138941 @default.
- W172511037 cites W1989975786 @default.
- W172511037 cites W1990291541 @default.
- W172511037 cites W1991115604 @default.
- W172511037 cites W1993449698 @default.
- W172511037 cites W1995093204 @default.
- W172511037 cites W1995391501 @default.
- W172511037 cites W1996878434 @default.
- W172511037 cites W1996926003 @default.
- W172511037 cites W1998158177 @default.
- W172511037 cites W1998949162 @default.
- W172511037 cites W1999269277 @default.
- W172511037 cites W2000263543 @default.
- W172511037 cites W2000678775 @default.
- W172511037 cites W2002266418 @default.
- W172511037 cites W2003007879 @default.
- W172511037 cites W2003877563 @default.
- W172511037 cites W2004142844 @default.
- W172511037 cites W2006639171 @default.
- W172511037 cites W2006719910 @default.
- W172511037 cites W2006960442 @default.
- W172511037 cites W2008085628 @default.
- W172511037 cites W2008161863 @default.
- W172511037 cites W2010146496 @default.
- W172511037 cites W2010203793 @default.
- W172511037 cites W2010938884 @default.
- W172511037 cites W2010955453 @default.
- W172511037 cites W2011918841 @default.
- W172511037 cites W2015949769 @default.
- W172511037 cites W2016323548 @default.
- W172511037 cites W2017528461 @default.
- W172511037 cites W2019209482 @default.
- W172511037 cites W2019904737 @default.
- W172511037 cites W2021153400 @default.
- W172511037 cites W2021908619 @default.
- W172511037 cites W2022222076 @default.
- W172511037 cites W2022497999 @default.
- W172511037 cites W2024517044 @default.
- W172511037 cites W2026093892 @default.
- W172511037 cites W2026377273 @default.
- W172511037 cites W2026694721 @default.
- W172511037 cites W2026859161 @default.
- W172511037 cites W2027429767 @default.
- W172511037 cites W2027829566 @default.
- W172511037 cites W2028061763 @default.
- W172511037 cites W2028438066 @default.
- W172511037 cites W2029641949 @default.
- W172511037 cites W2030377279 @default.
- W172511037 cites W2030783122 @default.
- W172511037 cites W2034610919 @default.
- W172511037 cites W2037181886 @default.
- W172511037 cites W2038237125 @default.
- W172511037 cites W2039436083 @default.
- W172511037 cites W2039506763 @default.
- W172511037 cites W2043847489 @default.
- W172511037 cites W2044884889 @default.
- W172511037 cites W2045122620 @default.
- W172511037 cites W2045621756 @default.
- W172511037 cites W2045972295 @default.