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- W172597075 abstract "Abnormal lipoprotein metabolism is a major predisposing factor to atherosclerosis. Dyslipidemia is present in over 70% of patients with premature coronary heart disease (CHD), (<60 years of age in men and <65 years in women) and over 50% of these patients have a familial lipoprotein disorder [1–3]. The genetic basis for several lipoprotein disorders has been elucidated in the past two decades. The majority of these disorders result from a combination of polygenic predisposition and poor lifestyle habits, including physical inactivity, increased visceral adipose tissue, increased caloric intake, and cigarette smoking. Monogenic disorders are less common; however, important to diagnose. Unraveling the genetic basis of many lipoprotein disorders has allowed fundamental discoveries in molecular cellular physiology and has paved the way for novel therapeutic approaches for CHD. This chapter describes the known inherited lipoprotein disorders." @default.
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- W172597075 date "2011-01-01" @default.
- W172597075 modified "2023-09-25" @default.
- W172597075 title "Inherited Lipoprotein Disorders" @default.
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- W172597075 doi "https://doi.org/10.1007/978-1-60327-502-6_4" @default.
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