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• W17263404 abstract "DNA samples from 60 Mapuche Indians, representing 39 maternal lineages, were genetically characterized for (1) nucleotide sequences of the mtDNA control region; (2) presence or absence of a nine base duplication in mtDNA region V; (3) HLA loci DRB1 and DQA1; (4) variation at three nuclear genes with short tandem repeats; and (5) variation at the polymorphic marker D2S44. The genetic profile of the Mapuche population was compared to other Amerinds and to worldwide populations. Two highly polymorphic portions of the mtDNA control region, comprising 650 nucleotides, were amplified by the polymerase chain reaction (PCR) and directly sequenced. The 39 maternal lineages were defined by two or three generation families identified by the Mapuches. These 39 lineages included 19 different mtDNA sequences that could be grouped into four classes. The same classes of sequences appear in other Amerinds from North, Central, and South American populations separated by thousands of miles, suggesting that the origin of the mtDNA patterns predates the migration to the Americas. The mtDNA sequence similarity between Amerind populations suggests that the migration throughout the Americas occurred rapidly relative to the mtDNA mutation rate. HLA DRBI alleles 1602 and 1402 were frequent among the Mapuches. These alleles also occur at high frequency among other Amerinds in North and South America, but not among Spanish, Chinese or African-American populations. The high frequency of these alleles throughout the Americas, and their specificity to the Americas, supports the hypothesis that Mapuches and other Amerind groups are closely related. Frequencies of alleles of the nuclear genes encoding renin, tyrosine hydroxylase, D2S44 and CD4 in the Mapuche population did not significantly differ from the frequencies found in Caucasian, African-American, MexicanAmerican, or Asian populations." @default.
• W17263404 created "2016-06-24" @default.
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• W17263404 date "1993-01-01" @default.
• W17263404 modified "2023-10-01" @default.
• W17263404 title "Genetic variation among the Mapuche Indians from the Patagonian region of Argentina: Mitochondrial DNA sequence variation and allele frequencies of several nuclear genes" @default.
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• W17263404 doi "https://doi.org/10.1007/978-3-0348-8583-6_17" @default.
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