FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1726449166> ?p ?o ?g. }

• W1726449166 endingPage "3002" @default.
• W1726449166 startingPage "2986" @default.
• W1726449166 abstract "Transmitted by the Aedes aegypti mosquito, the dengue virus is the etiological agent of dengue fever, dengue hemorrhagic fever and dengue shock syndrome, and, as such, is a significant factor in the high death rate found in most tropical and subtropical areas of the world. Dengue diseases are not only a health burden to developing countries, but pose an emerging problem worldwide. The immunopathological mechanisms appear to include a complex series of immune responses. A rapid increase in the levels of cytokines and chemical mediators during dengue disease plays a key role in inducing plasma leakage, shock and hemorrhagic manifestations. Currently, there are no vaccines available against dengue virus, although several tetravalent live‐attenuated dengue vaccines are in clinical phases I or II, and prevention through vaccination has become a major priority on the agendas of the World Health Organization and of national ministries of health and military organizations. An alternative to vaccines is found in therapeutic‐based approaches. Understanding the molecular mechanisms of viral replication has led to the development of potential drugs, and new molecular viral targets for therapy are emerging. The NS3 protease domain of the NS3 protein is responsible for processing the viral polyprotein and its inhibition is one of the principal aims of pharmacological therapy. This review is an overview of the progress made against dengue virus; in particular, it examines the unique properties – structural and functional – of the NS3 protease for the treatment of dengue virus infections by the inhibition of viral polyprotein processing." @default.
• W1726449166 created "2016-06-24" @default.
• W1726449166 creator A5022448244 @default.
• W1726449166 creator A5062081901 @default.
• W1726449166 date "2007-05-17" @default.
• W1726449166 modified "2023-10-17" @default.
• W1726449166 title "Progress for dengue virus diseases" @default.
• W1726449166 cites W1028484712 @default.
• W1726449166 cites W103443620 @default.
• W1726449166 cites W1497030000 @default.
• W1726449166 cites W1530508050 @default.
• W1726449166 cites W1557992389 @default.
• W1726449166 cites W1564935170 @default.
• W1726449166 cites W1570836961 @default.
• W1726449166 cites W1571993997 @default.
• W1726449166 cites W1579199588 @default.
• W1726449166 cites W1582754056 @default.
• W1726449166 cites W1585923643 @default.
• W1726449166 cites W1592374426 @default.
• W1726449166 cites W1622437624 @default.
• W1726449166 cites W1793827589 @default.
• W1726449166 cites W1865324159 @default.
• W1726449166 cites W1879379129 @default.
• W1726449166 cites W1901804918 @default.
• W1726449166 cites W1961155231 @default.
• W1726449166 cites W1963731038 @default.
• W1726449166 cites W1964886627 @default.
• W1726449166 cites W1966382036 @default.
• W1726449166 cites W1970140557 @default.
• W1726449166 cites W1972162083 @default.
• W1726449166 cites W1978035722 @default.
• W1726449166 cites W1981052336 @default.
• W1726449166 cites W1983015322 @default.
• W1726449166 cites W1983863966 @default.
• W1726449166 cites W1985008932 @default.
• W1726449166 cites W1985469117 @default.
• W1726449166 cites W1987702283 @default.
• W1726449166 cites W1992285108 @default.
• W1726449166 cites W1998178858 @default.
• W1726449166 cites W1998660158 @default.
• W1726449166 cites W2000363784 @default.
• W1726449166 cites W2002185589 @default.
• W1726449166 cites W2002545308 @default.
• W1726449166 cites W2003034517 @default.
• W1726449166 cites W2008786038 @default.
• W1726449166 cites W2010817652 @default.
• W1726449166 cites W2012551953 @default.
• W1726449166 cites W2012886516 @default.
• W1726449166 cites W2015593005 @default.
• W1726449166 cites W2020460356 @default.
• W1726449166 cites W2020552762 @default.
• W1726449166 cites W2020705949 @default.
• W1726449166 cites W2023671437 @default.
• W1726449166 cites W2027353448 @default.
• W1726449166 cites W2028064829 @default.
• W1726449166 cites W2029483874 @default.
• W1726449166 cites W2030439521 @default.
• W1726449166 cites W2037831589 @default.
• W1726449166 cites W2045845650 @default.
• W1726449166 cites W2049280865 @default.
• W1726449166 cites W2053115160 @default.
• W1726449166 cites W2053634079 @default.
• W1726449166 cites W2054173624 @default.
• W1726449166 cites W2055951448 @default.
• W1726449166 cites W2057065474 @default.
• W1726449166 cites W2057635506 @default.
• W1726449166 cites W2059469295 @default.
• W1726449166 cites W2060148547 @default.
• W1726449166 cites W2062725625 @default.
• W1726449166 cites W2068264550 @default.
• W1726449166 cites W2072897393 @default.
• W1726449166 cites W2073689635 @default.
• W1726449166 cites W2073855398 @default.
• W1726449166 cites W2073993998 @default.
• W1726449166 cites W2074188269 @default.
• W1726449166 cites W2074951994 @default.
• W1726449166 cites W2075582324 @default.
• W1726449166 cites W2077562743 @default.
• W1726449166 cites W2078798933 @default.
• W1726449166 cites W2079866702 @default.
• W1726449166 cites W2079949399 @default.
• W1726449166 cites W2083009436 @default.
• W1726449166 cites W2086221905 @default.
• W1726449166 cites W2089569416 @default.
• W1726449166 cites W2091379422 @default.
• W1726449166 cites W2091937293 @default.
• W1726449166 cites W2095300338 @default.
• W1726449166 cites W2098391509 @default.
• W1726449166 cites W2100865800 @default.
• W1726449166 cites W2102560085 @default.
• W1726449166 cites W2113039776 @default.
• W1726449166 cites W2113440189 @default.
• W1726449166 cites W2113583073 @default.
• W1726449166 cites W2113638843 @default.
• W1726449166 cites W2113967550 @default.
• W1726449166 cites W2114555149 @default.
• W1726449166 cites W2121789542 @default.
• W1726449166 cites W2124483903 @default.

• next