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- W172752935 abstract "Restenosis and thrombosis are undesired effects after stent implantation. Reduced or missing re-endothelialization of injured coronary arteries shall be abolished by improving stem cell homing at the side of injury to support their differentiation into intact endothelium. We developed a bifunctional protein binding to collagen at the vessel lesion site and to stem/progenitor cells. ELISA studies demonstrated that this bifunctional protein binds to collagen type1 comparably strong as the control protein. Employing stem cell marker overexpressing cells and human CD34+ endothelial progenitor cells on a multi substrate array (MSA) spotted with 14 different extracellular matrix proteins demonstrated the bifunctionality and specificity of the protein. This specificity was substantiated in flow chamber adhesion experiments. Furthermore, we tested colony forming ability and by this endothelial like differentiation of CD34+-cells on fusion protein coated surfaces. In conclusion, this bifunctional protein is a promising construct to support re-endothelialization and therefore reducing restenosis and thrombosis risk after stent implantation. Supported by the German Ministry of Education and Research (BMBF) # 01GU0727 and 01GU0726." @default.
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- W172752935 date "2010-04-01" @default.
- W172752935 modified "2023-10-17" @default.
- W172752935 title "Bifunctional protein for improved stent performance and endothelial regeneration" @default.
- W172752935 doi "https://doi.org/10.1096/fasebj.24.1_supplement.644.8" @default.
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