FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W172759983> ?p ?o ?g. }

• W172759983 abstract "Around 3% of the general population suffers a first episode of psychosis (FEP). The population of FEPs represents a unique opportunity to study psychotic disorders in general and schizophrenia in particular, avoiding confounding variables such as antipsychotic treatment, comorbidity and chronicity. Several hypotheses that involve the immune system and neuroinflammatory processes have been proposed as etiological explanations of psychosis. Most of the available scientific evidence has been found in populations with established schizophrenia. Few studies indicate alterations, often subtle, in inflammatory/immune mediators and oxidative/nitrosative stress in FEPs. One of the main anti-inflammatory endogenous regulatory systems is the endocannabinoid system (ECS), which has been proposed as a major homeostatic system at various neuropathological scenarios, reducing both neurodegenerative and neuroinflammatory damage. Several studies have linked the ECS in patients with psychotic disorders. Furthermore, exogenous cannabis is one of the major environmental risk factors related to psychosis. In a first study, 117 FEPs showed systemic inflammatory conditions compared to 106 healthy controls, identifying a significant increase in some intracellular components of the NFKB proinflammatory pathway, together with a significant reduction in the anti-inflammatory components of the 15d-PGJ2/PPARy pathway. The expression of iNOS and COX-2 in PBMC and plasma levels of Homocysteine were identified as the most reliable risk factors, and I?B? and the 15d-PGJ2 as potential protective factors. These results indicate robust phenotypic differences at cellular machinery in PBMC of patients with a FEP. Due to its soluble nature, one notable finding of this study is that the anti-inflammatory mediator 15d- PGJ2 could be used as a plasma biomarker of FEPs. A second study reinforced the evidence of systemic inflammatory changes after a 6-month follow-up of the sample of FEPs. After 6 months, most of the soluble elements analyzed were significantly altered, suggesting the existence of a greater pro/anti-inflammatory imbalance and potentially more harmful, as showed the lipid peroxidation (TBARS) found. NO2- plasma levels and TBARS and COX-2 expression were the most reliable risk factors, while plasma levels of 15d-PGJ2 functioned as a protective factor. There was an interesting correlation between antipsychotic dose and the change of PGE2 (inverse) and 15d-PGJ2 (direct).There was also an inverse association between the GAF scale and TBARS. In a third study, a peripheral ECS dysregulation in patients with a FEP was described. After controlling for age, sex, body mass index and cannabis use, the FEP group showed a significantly reduced expression of the main synthesis enzymes (NAPE and DAGL) and increased degradation enzymes (FAAH and MAGL). The subgroup of patients with a history of heavy cannabis users showed lower CB2 receptor, NAPE and DAGL expression compared with the control group. No significant differences were found with non-users/sporadic subgroup. Although more evidence is needed, this research shows how the determination of several components of the pro/anti-inflammatory pathways and the ECS has an interesting potential as biomarkers risk/protective biomarkers of suffering a FEP. Despite the limitations, the studies of this thesis have identified conditions of vulnerability to suffer a FEP related to pro/anti-inflammatory pathways and peripheral ECS components in a very well characterized sample of FEPs." @default.
• W172759983 created "2016-06-24" @default.
• W172759983 creator A5074097565 @default.
• W172759983 date "2013-10-14" @default.
• W172759983 modified "2023-09-26" @default.
• W172759983 title "Neuroinflammation in first episodes of psychosis" @default.
• W172759983 cites W1225620574 @default.
• W172759983 cites W123990481 @default.
• W172759983 cites W1491109154 @default.
• W172759983 cites W153418226 @default.
• W172759983 cites W1591881963 @default.
• W172759983 cites W1594425991 @default.
• W172759983 cites W1903625870 @default.
• W172759983 cites W1938316342 @default.
• W172759983 cites W1955724354 @default.
• W172759983 cites W1963805149 @default.
• W172759983 cites W1964019154 @default.
• W172759983 cites W1964143890 @default.
• W172759983 cites W1965196441 @default.
• W172759983 cites W1965613140 @default.
• W172759983 cites W1965724486 @default.
• W172759983 cites W1970456212 @default.
• W172759983 cites W1970460183 @default.
• W172759983 cites W1970606114 @default.
• W172759983 cites W1971277158 @default.
• W172759983 cites W1972713412 @default.
• W172759983 cites W1973948212 @default.
• W172759983 cites W1974569416 @default.
• W172759983 cites W1974996721 @default.
• W172759983 cites W1976127510 @default.
• W172759983 cites W1978238793 @default.
• W172759983 cites W1978663763 @default.
• W172759983 cites W1978722353 @default.
• W172759983 cites W1979665154 @default.
• W172759983 cites W1980524078 @default.
• W172759983 cites W1980862554 @default.
• W172759983 cites W1981101682 @default.
• W172759983 cites W1982474832 @default.
• W172759983 cites W1984623538 @default.
• W172759983 cites W1986356926 @default.
• W172759983 cites W1986890804 @default.
• W172759983 cites W1988936042 @default.
• W172759983 cites W1989554135 @default.
• W172759983 cites W1992557727 @default.
• W172759983 cites W1994083049 @default.
• W172759983 cites W1996254896 @default.
• W172759983 cites W2000451610 @default.
• W172759983 cites W2001750328 @default.
• W172759983 cites W2003106369 @default.
• W172759983 cites W2004630955 @default.
• W172759983 cites W2004655911 @default.
• W172759983 cites W2008546357 @default.
• W172759983 cites W2009928774 @default.
• W172759983 cites W2014596655 @default.
• W172759983 cites W2015075518 @default.
• W172759983 cites W2016135515 @default.
• W172759983 cites W2016730049 @default.
• W172759983 cites W2021813448 @default.
• W172759983 cites W2024908874 @default.
• W172759983 cites W2025056228 @default.
• W172759983 cites W2025205883 @default.
• W172759983 cites W2025245489 @default.
• W172759983 cites W2026122923 @default.
• W172759983 cites W2029256011 @default.
• W172759983 cites W2030396834 @default.
• W172759983 cites W2033429072 @default.
• W172759983 cites W2038092706 @default.
• W172759983 cites W2039335406 @default.
• W172759983 cites W2039560209 @default.
• W172759983 cites W2040080264 @default.
• W172759983 cites W2042755650 @default.
• W172759983 cites W2043583313 @default.
• W172759983 cites W2045054186 @default.
• W172759983 cites W2046326883 @default.
• W172759983 cites W2047591801 @default.
• W172759983 cites W2047797335 @default.
• W172759983 cites W2048249572 @default.
• W172759983 cites W2048308338 @default.
• W172759983 cites W2049854720 @default.
• W172759983 cites W2051543576 @default.
• W172759983 cites W2052480269 @default.
• W172759983 cites W2052794650 @default.
• W172759983 cites W2052908553 @default.
• W172759983 cites W2053221584 @default.
• W172759983 cites W2054685711 @default.
• W172759983 cites W2054998761 @default.
• W172759983 cites W2056993604 @default.
• W172759983 cites W2057349855 @default.
• W172759983 cites W2057690098 @default.
• W172759983 cites W2057758167 @default.
• W172759983 cites W2059202821 @default.
• W172759983 cites W2060038783 @default.
• W172759983 cites W2060584674 @default.
• W172759983 cites W2061002013 @default.
• W172759983 cites W2061663043 @default.
• W172759983 cites W2063711010 @default.
• W172759983 cites W2063832465 @default.
• W172759983 cites W2066985048 @default.
• W172759983 cites W2067731331 @default.
• W172759983 cites W2069582379 @default.

• next