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- W1728199786 endingPage "293" @default.
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- W1728199786 abstract "Publisher Summary This chapter describes the different aspects of antifungal drugs. The susceptibility factors and drug interaction of allylamines and amphotericin are reviewed. In a multicenter, randomized, double-blind, parallel-group study, 63 patients aged 14–85 years with Sporothrix schenckii infections were treated with terbinafine 500 mg/day. Cutaneous adverse effects reportedly occur in 1–3% of patients taking terbinafine. Limited data suggest that the safety profile of terbinafine in children is not different from that observed in adults and that terbinafine is well tolerated in this population over short periods of time. It is found that compared with conventional amphotericin B deoxycholate, lipid-based formulations are less nephrotoxic. In a randomized, controlled trial in 105 adults with hematological malignancies and fever of unknown origin after chemotherapy or autologous stem cell trans-plantation, amphotericin was used as empirical antifungal therapy. Drug interactions with the antifungal azoles are continually reported. They are common, because these drugs are potent inhibitors of CYP isozymes and P glycoprotein. The effects of ketoconazole 200 mg/day for 3 days on the pharmacokinetics of docetaxel 100 mg/m 2 have also been studied." @default.
- W1728199786 created "2016-06-24" @default.
- W1728199786 creator A5032935188 @default.
- W1728199786 creator A5071800632 @default.
- W1728199786 date "2007-01-01" @default.
- W1728199786 modified "2023-09-27" @default.
- W1728199786 title "27 Antifungal drugs" @default.
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