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- W172849889 abstract "Using strict diagnostic criteria, a clinical trial of cefoxitin as the only antimicrobial agent in the treatment of twenty-five cases of septic abortion was carried out. The success rate of 77% (seventeen out of twenty-two) was significant in this group of seriously ill patients of low social class. Presence of pelvic abscess does not seem to preclude the use of cefoxitin. While the infections were of mixed bacterial flora, anaerobes were the predominant organisms isolated. Most organisms isolated were sensitive to cefoxitin but Pseudomonas aeruginosa was markedly resistant. No untoward reactions were observed. It appears that cefoxitin was successful as a single agent in the treatment of septic abortion.An uncontrolled clinical trail was carried out to assess the efficacy of cefoxitin as the sole antimicrobial agent in the treatment of 22 cases of septic abortion in Lagos, Nigeria. The mean age of patients studied was 21 years; 90% were from social classes IV and V. All study subjects satisfied the following diagnostic criteria: pyrexia of equal to or greater than 38 C, tachycardia equal to or greater than 90/min, foul smelling vaginal discharge, uterine tenderness, adnexal tenderness, peritonitis, or features of septicemia. All patients received initial doses of 2 gm of cefoxitin sodium by slow intravenous bolus and then 2 gm every 6 hours for the next 5 days. 17 (77%) of the patients improved on cefoxitin therapy. There was no mortality and no serious side effects. The mean duration of hospital stay was 9 days for the patients who responded to cefoxitin and 21 days for patients whose conditions was not improved by this treatment. Anaerobes, especially Bacteriodes bivius, were isolated from all 22 patients. 4 of the 5 patients who did not respond to 72 hours of treatment with cefoxitin harbored organisms such as Pseudomonas aeruginosa that are resistant to this drug. None of the patients treated with cefoxitin progressed to abscess formation. These findings suggest that cefoxitin can be used as a single antimicrobial agent in the treatment of septic abortion and may offer advantages over the use of a combination of antimicrobials." @default.
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- W172849889 date "1986-03-01" @default.
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- W172849889 title "Cefoxitin: single agent treatment of septic abortion." @default.
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