FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1728994403> ?p ?o ?g. }

• W1728994403 endingPage "3197" @default.
• W1728994403 startingPage "3194" @default.
• W1728994403 abstract "The attenuated phenotype of Sabin 3 poliovirus compared with its neurovirulent progenitor strain has been largely accounted for by mutations in the genome at positions 472 and 2034 (G. D. Westrop, K. A. Wareham, D. M. A. Evans, G. Dunn, P. D. Minor, D. I. Magrath, F. Taffs, S. Marsden, M. A. Skinner, G. C. Schild, and J. W. Almond, J. Virol. 63:1338-1344, 1989). By sequencing vaccine virus RNA, we recently identified another Sabin 3-specific mutation at position 2493 (U----C), which predicts an Ile----Thr change at the sixth residue of VP1 (C. Weeks-Levy, J. M. Tatem, S. J. DiMichele, W. Waterfield, A. F. Georgiu, and S. J. Mento, Virology 185:934-937, 1991). Viruses generated by using cDNAs which represent the vaccine sequence (LED3) and a derivative (VR318) possessing a single base change to the wild-type nucleotide (U) at 2493 were used to determine the impact of the 2493 mutation on virus phenotype. The VP1 proteins of LED3 and VR318 viruses were distinguishable by denaturing electrophoretic analysis. LED3 produced smaller plaques in Vero cells than VR318 virus did. Neurovirulence testing of these cDNA-derived viruses in monkeys demonstrated that the 2493 mutation in LED3 virus is attenuating." @default.
• W1728994403 created "2016-06-24" @default.
• W1728994403 creator A5009082010 @default.
• W1728994403 creator A5022391999 @default.
• W1728994403 creator A5027928774 @default.
• W1728994403 creator A5032432011 @default.
• W1728994403 creator A5038735531 @default.
• W1728994403 creator A5038820914 @default.
• W1728994403 creator A5069982051 @default.
• W1728994403 creator A5080318036 @default.
• W1728994403 date "1992-05-01" @default.
• W1728994403 modified "2023-10-01" @default.
• W1728994403 title "A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating" @default.
• W1728994403 cites W1484360748 @default.
• W1728994403 cites W150025772 @default.
• W1728994403 cites W1556533824 @default.
• W1728994403 cites W1570828652 @default.
• W1728994403 cites W1579841907 @default.
• W1728994403 cites W1589081180 @default.
• W1728994403 cites W1853272854 @default.
• W1728994403 cites W1923030653 @default.
• W1728994403 cites W1993392704 @default.
• W1728994403 cites W2010259434 @default.
• W1728994403 cites W2010608454 @default.
• W1728994403 cites W2013676379 @default.
• W1728994403 cites W2017367016 @default.
• W1728994403 cites W2018289835 @default.
• W1728994403 cites W2020764512 @default.
• W1728994403 cites W2029618072 @default.
• W1728994403 cites W2030583381 @default.
• W1728994403 cites W2047976861 @default.
• W1728994403 cites W2060520834 @default.
• W1728994403 cites W2100837269 @default.
• W1728994403 cites W2124934598 @default.
• W1728994403 cites W2146894910 @default.
• W1728994403 cites W2463571081 @default.
• W1728994403 cites W4242465210 @default.
• W1728994403 doi "https://doi.org/10.1128/jvi.66.5.3194-3197.1992" @default.
• W1728994403 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/241086" @default.
• W1728994403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1313923" @default.
• W1728994403 hasPublicationYear "1992" @default.
• W1728994403 type Work @default.
• W1728994403 sameAs 1728994403 @default.
• W1728994403 citedByCount "57" @default.
• W1728994403 countsByYear W17289944032013 @default.
• W1728994403 countsByYear W17289944032014 @default.
• W1728994403 countsByYear W17289944032015 @default.
• W1728994403 countsByYear W17289944032016 @default.
• W1728994403 countsByYear W17289944032018 @default.
• W1728994403 countsByYear W17289944032023 @default.
• W1728994403 crossrefType "journal-article" @default.
• W1728994403 hasAuthorship W1728994403A5009082010 @default.
• W1728994403 hasAuthorship W1728994403A5022391999 @default.
• W1728994403 hasAuthorship W1728994403A5027928774 @default.
• W1728994403 hasAuthorship W1728994403A5032432011 @default.
• W1728994403 hasAuthorship W1728994403A5038735531 @default.
• W1728994403 hasAuthorship W1728994403A5038820914 @default.
• W1728994403 hasAuthorship W1728994403A5069982051 @default.
• W1728994403 hasAuthorship W1728994403A5080318036 @default.
• W1728994403 hasBestOaLocation W17289944031 @default.
• W1728994403 hasConcept C104317684 @default.
• W1728994403 hasConcept C153911025 @default.
• W1728994403 hasConcept C156719811 @default.
• W1728994403 hasConcept C159047783 @default.
• W1728994403 hasConcept C182707283 @default.
• W1728994403 hasConcept C2522874641 @default.
• W1728994403 hasConcept C2779631682 @default.
• W1728994403 hasConcept C2779755945 @default.
• W1728994403 hasConcept C501734568 @default.
• W1728994403 hasConcept C54355233 @default.
• W1728994403 hasConcept C67705224 @default.
• W1728994403 hasConcept C86803240 @default.
• W1728994403 hasConcept C89138240 @default.
• W1728994403 hasConceptScore W1728994403C104317684 @default.
• W1728994403 hasConceptScore W1728994403C153911025 @default.
• W1728994403 hasConceptScore W1728994403C156719811 @default.
• W1728994403 hasConceptScore W1728994403C159047783 @default.
• W1728994403 hasConceptScore W1728994403C182707283 @default.
• W1728994403 hasConceptScore W1728994403C2522874641 @default.
• W1728994403 hasConceptScore W1728994403C2779631682 @default.
• W1728994403 hasConceptScore W1728994403C2779755945 @default.
• W1728994403 hasConceptScore W1728994403C501734568 @default.
• W1728994403 hasConceptScore W1728994403C54355233 @default.
• W1728994403 hasConceptScore W1728994403C67705224 @default.
• W1728994403 hasConceptScore W1728994403C86803240 @default.
• W1728994403 hasConceptScore W1728994403C89138240 @default.
• W1728994403 hasIssue "5" @default.
• W1728994403 hasLocation W17289944031 @default.
• W1728994403 hasLocation W17289944032 @default.
• W1728994403 hasLocation W17289944033 @default.
• W1728994403 hasLocation W17289944034 @default.
• W1728994403 hasOpenAccess W1728994403 @default.
• W1728994403 hasPrimaryLocation W17289944031 @default.
• W1728994403 hasRelatedWork W1651603825 @default.
• W1728994403 hasRelatedWork W174127594 @default.
• W1728994403 hasRelatedWork W1942718106 @default.
• W1728994403 hasRelatedWork W1998581623 @default.
• W1728994403 hasRelatedWork W2018006620 @default.

• next