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- W1729088122 endingPage "5058" @default.
- W1729088122 startingPage "5016" @default.
- W1729088122 abstract "Halichondrin B is a complex, natural, polyether macrolide derived from marine sponges. Eribulin is a structurally-simplified, synthetic, macrocyclic ketone analogue of Halichondrin B. Eribulin was approved by United States Food and Drug Administration in 2010 as a third-line therapy for metastatic breast cancer patients who have previously been treated with an anthracycline and a taxane. It has a unique microtubule dynamics inhibitory action. Phase III studies have either been completed or are currently ongoing in breast cancer, soft tissue sarcoma, and non-small cell lung cancer. Phase I and II studies in multiple cancers and various combinations are currently ongoing. This article reviews the available information on eribulin with respect to its clinical pharmacology, pharmacokinetics, pharmacodynamics, mechanism of action, metabolism, preclinical studies, and with special focus on clinical trials." @default.
- W1729088122 created "2016-06-24" @default.
- W1729088122 creator A5029455802 @default.
- W1729088122 creator A5034103357 @default.
- W1729088122 creator A5083949476 @default.
- W1729088122 date "2015-08-07" @default.
- W1729088122 modified "2023-10-14" @default.
- W1729088122 title "Eribulin in Cancer Treatment" @default.
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- W1729088122 doi "https://doi.org/10.3390/md13085016" @default.