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• W172914587 abstract "Over the past two decades it has become increasingly apparent that xenobiotic agents can directly influence transcriptional regulation of gene expression without producing detectable changes in the structure of DNA. The response of a cell to its environment is a dynamic process in which differentiation-driven paradigms for gene expression can be modulated by both endogenous and exogenous extracellular agents. Typical outcomes include: altered cell function, changes in proliferation and/or regulation of cell growth or cell death. Altered gene expression is often the result of a physiologically programmed interaction between the cell and a regulatory hormone or cytokine. Alternatively, altered gene expression can result from an interaction of the cell with a xenobiotic molecule. In many cases the consequences of these apparently disparate events, as well as their biochemistry, do not appear to be remarkably different. Our laboratory has been investigating the role of altered transcriptional regulation in the response of hematopoietic and immune cells to xenobiotic agents as one approach to understanding molecular mechanisms of toxicity and also with a view toward exploring whether altered patterns of transcriptional regulation can be used as a tool for predicting the target organ toxicity of xenobiotic agents. Results of these studies suggest that the effects of biological reactive intermediates on transcriptional regulation of gene expression are cell-type specific and that the response of individual target cells is at least in part determined by differentiation-dependent patterns of signal transduction and gene expression." @default.
• W172914587 created "2016-06-24" @default.
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• W172914587 date "2001-01-01" @default.
• W172914587 modified "2023-09-26" @default.
• W172914587 title "Hematopoietic Stem and Progenitor Cells as Targets for Biological Reactive Intermediates" @default.
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• W172914587 doi "https://doi.org/10.1007/978-1-4615-0667-6_66" @default.
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