Matches in SemOpenAlex for { <https://semopenalex.org/work/W1729209718> ?p ?o ?g. }
- W1729209718 endingPage "11149" @default.
- W1729209718 startingPage "11139" @default.
- W1729209718 abstract "Chordomas are primary malignant tumors of the notochord that are resistant to conventional chemotherapy. Expression of programmed cell death ligand 1 (PD-L1), prevalence of tumor-infiltrating lymphocytes (TILs), and their clinical relevance in chordoma remain unknown. We evaluated PD-L1 expression in three chordoma cell lines and nine chordoma tissue samples by western blot. Immunohistochemical staining was performed on a chordoma tissue microarray (TMA) that contained 78 tissue specimens. We also correlated the expression of PD-L1 and TILs with clinical outcomes. PD-L1 protein expression was demonstrated to be induced by IFN-γ in both UCH1 and UCH2 cell lines. Across nine human chordoma tissue samples, PD-L1 protein was differentially expressed. 94.9% of chordoma samples showed positive PD-L1 expression in the TMA. The expression score of PD-L1 for metastatic chordoma tumors was significant higher as compared with non-metastatic chordoma tumors. Expression of PD-L1 protein significantly correlates with the presence of elevated TILs, which correlates with metastasis. In summary, our study showed high levels of PD-L1 are expressed in chordoma, which is correlated with the prevalence of TILs. The current study suggests targeting PD-L1 may be a novel immunotherapeutic strategy for chordoma clinical trials." @default.
- W1729209718 created "2016-06-24" @default.
- W1729209718 creator A5011930055 @default.
- W1729209718 creator A5016221246 @default.
- W1729209718 creator A5033769845 @default.
- W1729209718 creator A5034127151 @default.
- W1729209718 creator A5038077156 @default.
- W1729209718 creator A5055817420 @default.
- W1729209718 creator A5066463949 @default.
- W1729209718 creator A5071532449 @default.
- W1729209718 creator A5075139931 @default.
- W1729209718 creator A5082130171 @default.
- W1729209718 date "2015-03-14" @default.
- W1729209718 modified "2023-10-01" @default.
- W1729209718 title "Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma" @default.
- W1729209718 cites W1563804318 @default.
- W1729209718 cites W1724556032 @default.
- W1729209718 cites W1976269164 @default.
- W1729209718 cites W1981934675 @default.
- W1729209718 cites W1983082201 @default.
- W1729209718 cites W1990779902 @default.
- W1729209718 cites W1994238092 @default.
- W1729209718 cites W1997462426 @default.
- W1729209718 cites W2004630197 @default.
- W1729209718 cites W2007419457 @default.
- W1729209718 cites W2007852760 @default.
- W1729209718 cites W2010121426 @default.
- W1729209718 cites W2013090484 @default.
- W1729209718 cites W2016732129 @default.
- W1729209718 cites W2016983859 @default.
- W1729209718 cites W2018968534 @default.
- W1729209718 cites W2024318366 @default.
- W1729209718 cites W2025596075 @default.
- W1729209718 cites W2031837771 @default.
- W1729209718 cites W2036489403 @default.
- W1729209718 cites W2036951052 @default.
- W1729209718 cites W2050302729 @default.
- W1729209718 cites W2051455650 @default.
- W1729209718 cites W2052727153 @default.
- W1729209718 cites W2053627244 @default.
- W1729209718 cites W2056828743 @default.
- W1729209718 cites W2057893793 @default.
- W1729209718 cites W2065319085 @default.
- W1729209718 cites W2072553934 @default.
- W1729209718 cites W2081070412 @default.
- W1729209718 cites W2083262432 @default.
- W1729209718 cites W2083486480 @default.
- W1729209718 cites W2084281756 @default.
- W1729209718 cites W2099252068 @default.
- W1729209718 cites W2099491780 @default.
- W1729209718 cites W2100413206 @default.
- W1729209718 cites W2101653483 @default.
- W1729209718 cites W2107806760 @default.
- W1729209718 cites W2109485845 @default.
- W1729209718 cites W2112927491 @default.
- W1729209718 cites W2114974670 @default.
- W1729209718 cites W2116371946 @default.
- W1729209718 cites W2118982164 @default.
- W1729209718 cites W2130207101 @default.
- W1729209718 cites W2136313650 @default.
- W1729209718 cites W2155464214 @default.
- W1729209718 cites W2155899435 @default.
- W1729209718 cites W2160834915 @default.
- W1729209718 cites W2161558877 @default.
- W1729209718 cites W2162889226 @default.
- W1729209718 cites W2168654351 @default.
- W1729209718 cites W2560367415 @default.
- W1729209718 cites W4230861071 @default.
- W1729209718 cites W4242962877 @default.
- W1729209718 cites W4300052455 @default.
- W1729209718 doi "https://doi.org/10.18632/oncotarget.3576" @default.
- W1729209718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4484445" @default.
- W1729209718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25871477" @default.
- W1729209718 hasPublicationYear "2015" @default.
- W1729209718 type Work @default.
- W1729209718 sameAs 1729209718 @default.
- W1729209718 citedByCount "86" @default.
- W1729209718 countsByYear W17292097182015 @default.
- W1729209718 countsByYear W17292097182016 @default.
- W1729209718 countsByYear W17292097182017 @default.
- W1729209718 countsByYear W17292097182018 @default.
- W1729209718 countsByYear W17292097182019 @default.
- W1729209718 countsByYear W17292097182020 @default.
- W1729209718 countsByYear W17292097182021 @default.
- W1729209718 countsByYear W17292097182022 @default.
- W1729209718 countsByYear W17292097182023 @default.
- W1729209718 crossrefType "journal-article" @default.
- W1729209718 hasAuthorship W1729209718A5011930055 @default.
- W1729209718 hasAuthorship W1729209718A5016221246 @default.
- W1729209718 hasAuthorship W1729209718A5033769845 @default.
- W1729209718 hasAuthorship W1729209718A5034127151 @default.
- W1729209718 hasAuthorship W1729209718A5038077156 @default.
- W1729209718 hasAuthorship W1729209718A5055817420 @default.
- W1729209718 hasAuthorship W1729209718A5066463949 @default.
- W1729209718 hasAuthorship W1729209718A5071532449 @default.
- W1729209718 hasAuthorship W1729209718A5075139931 @default.
- W1729209718 hasAuthorship W1729209718A5082130171 @default.
- W1729209718 hasBestOaLocation W17292097181 @default.