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• W172926881 abstract "This chapter discusses the control of protein turnover in the isolated perfused rat heart. Protein turnover and its hormonal and nonhormonal control was studied in an isolated preparation of perfused rat heart muscle. This preparation permits the control of protein turnover to be examined under well-defined conditions as the level of ventricular pressure development, heart rate, left atrial filling pressure, and coronary flow can be controlled. Levels of protein within cardiac muscle may vary either as a result of changes in the rates of protein synthesis or degradation. In a study described in the chapter, the rates of degradation were estimated by measuring release of phenylalanine from the heart. Net release of phenylalanine would not occur if rates of synthesis and degradation were equal. An approximation of the rate of degradation could be made by measuring the rate of dilution of the specific activity of the free phenylalanine pool. This method underestimated the rate of degradation by the extent to which exchange of phenylalanine across the cell membrane prevented equilibration of the specific activities of the intracellular and extracellular pools of the amino acids." @default.
• W172926881 created "2016-06-24" @default.
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• W172926881 date "1975-01-01" @default.
• W172926881 modified "2023-09-26" @default.
• W172926881 title "The Control of Protein Turnover in the Isolated Perfused Rat Heart**Supported by grant number HE-11534 and contract number NHLI-71-2499, from the National Institutes of Health." @default.
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• W172926881 doi "https://doi.org/10.1016/b978-0-08-017708-3.50017-3" @default.
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