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• W1729312 startingPage "1449" @default.
• W1729312 abstract "The signaling cascade involved in chemosensory transduction in the VN organ is incompletely understood. In snakes, the response to nonvolatile prey chemicals is mediated by the vomeronasal (VN) system. Using optical techniques and fluorescent Ca(2+) indicators, we found that prey-derived chemoattractants produce initially a transient cytosolic accumulation of [Ca(2+)](i) in the dendritic regions of VN neurons via two pathways: Ca(2+) release from IP(3)-sensitive intracellular stores and, to a lesser extent, Ca(2+) influx through the plasma membrane. Both components seem to be dependent on IP(3) production. Chemoattractants evoke a short-latency Ca(2+) elevation even in the absence of extracellular Ca(2+), suggesting that in snake VN neurons, Ca(2+) release from intracellular stores is independent of a preceding Ca(2+) influx, and both components are activated in parallel during early stages of chemosensory transduction. Once the response develops in apical dendritic segments, other mechanisms can also contribute to the amplification and modulation of these chemoattractant-mediated cytosolic Ca(2+) transients. In regions close to the cell bodies of the VN neurons, the activation of voltage-sensitive Ca(2+) channels and a Ca(2+)-induced Ca(2+) release from intracellular ryanodine-sensitive stores secondarily boost initial cytosolic Ca(2+) elevations increasing their magnitude and durations. Return of intracellular Ca(2+) to prestimulation levels appears to involve a Ca(2+) extrusion mediated by a Na(+)/Ca(2+) exchanger mechanism that probably plays an important role in limiting the magnitude and duration of the stimulation-induced Ca(2+) transients." @default.
• W1729312 created "2016-06-24" @default.
• W1729312 creator A5019687804 @default.
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• W1729312 creator A5030978586 @default.
• W1729312 creator A5051480539 @default.
• W1729312 creator A5068974304 @default.
• W1729312 date "2002-03-01" @default.
• W1729312 modified "2023-09-27" @default.
• W1729312 title "Calcium Transients in the Garter Snake Vomeronasal Organ" @default.
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• W1729312 doi "https://doi.org/10.1152/jn.00651.2001" @default.
• W1729312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11877519" @default.
• W1729312 hasPublicationYear "2002" @default.
• W1729312 type Work @default.

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