Matches in SemOpenAlex for { <https://semopenalex.org/work/W17295524> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W17295524 endingPage "9" @default.
- W17295524 startingPage "S3" @default.
- W17295524 abstract "Circulating and vascular endothelin-1 (ET-1) levels are elevated in diabetes, but the molecular components of the enzymatic activation of ET-1 in the vasculature remains unknown. Furthermore, the distribution of ET receptors favors a contractile phenotype in African Americans with diabetes. Whether there is any difference in local ET-1 activation in this population is unknown. This study examined the expression and activity of ET converting enzyme-1 subisoforms (ECE-1) in the internal mammary artery specimens obtained from patients undergoing coronary artery bypass grafting. The study groups included African-American (AA) and Caucasian (CA), nondiabetic (ND) and diabetic (D) patients: AAND N = 10, CAND N = 9, AAD N = 9, and CAD N = 11. The expression of ECE-1 a, ECE-1 b and ECE-1c subisoforms was studied by RT-PCR. ECE-1 a was upregulated 2- and 4-fold in the CAD and MD groups, respectively (P < .05). In African-American patient groups, ECE-1 activity (fmol/ mg protein.h) was augmented from 2,804 +/- 185 in nondiabetic tissue samples to 6,857 +/- 393 in the diabetic tissue (P < .05). There was a similar increase in the CAD group, which did not significantly differ from AA diabetics. ECE-1 inhibitors, phosphoramidon and FR-901533, inhibited vascular ECE-1 activity by more than 80%. While neutral endopeptidase (NEP) and matrix metalloproteinase-2 (MMP-2) are able to process big ET-1, inhibitors of NEP (thiorphan) and MMP (batimistat) did not affect ECE-1 activity. In conclusion, the enzymatic pathway essential for generating vascular ET-1 is activated in the vasculature of both AA and CA diabetic patients and this activation is highly specific for ECE-1." @default.
- W17295524 created "2016-06-24" @default.
- W17295524 creator A5039930772 @default.
- W17295524 creator A5044447604 @default.
- W17295524 creator A5054339545 @default.
- W17295524 creator A5054743629 @default.
- W17295524 creator A5056831262 @default.
- W17295524 creator A5064465358 @default.
- W17295524 creator A5072730832 @default.
- W17295524 date "2002-01-01" @default.
- W17295524 modified "2023-09-23" @default.
- W17295524 title "Vascular endothelin converting enzyme-1 expression and activity is upregulated in clinical diabetes." @default.
- W17295524 cites W1504236746 @default.
- W17295524 cites W1796385735 @default.
- W17295524 cites W1972565751 @default.
- W17295524 cites W2014605254 @default.
- W17295524 cites W204492468 @default.
- W17295524 cites W2049397775 @default.
- W17295524 cites W2056551448 @default.
- W17295524 cites W2060407689 @default.
- W17295524 cites W2071957639 @default.
- W17295524 cites W2160590082 @default.
- W17295524 cites W2162804111 @default.
- W17295524 cites W2333159847 @default.
- W17295524 cites W2407464564 @default.
- W17295524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12477147" @default.
- W17295524 hasPublicationYear "2002" @default.
- W17295524 type Work @default.
- W17295524 sameAs 17295524 @default.
- W17295524 citedByCount "1" @default.
- W17295524 crossrefType "journal-article" @default.
- W17295524 hasAuthorship W17295524A5039930772 @default.
- W17295524 hasAuthorship W17295524A5044447604 @default.
- W17295524 hasAuthorship W17295524A5054339545 @default.
- W17295524 hasAuthorship W17295524A5054743629 @default.
- W17295524 hasAuthorship W17295524A5056831262 @default.
- W17295524 hasAuthorship W17295524A5064465358 @default.
- W17295524 hasAuthorship W17295524A5072730832 @default.
- W17295524 hasConcept C104317684 @default.
- W17295524 hasConcept C104826730 @default.
- W17295524 hasConcept C109523444 @default.
- W17295524 hasConcept C126322002 @default.
- W17295524 hasConcept C127561419 @default.
- W17295524 hasConcept C134018914 @default.
- W17295524 hasConcept C144980905 @default.
- W17295524 hasConcept C149601957 @default.
- W17295524 hasConcept C170493617 @default.
- W17295524 hasConcept C181199279 @default.
- W17295524 hasConcept C185592680 @default.
- W17295524 hasConcept C2780268870 @default.
- W17295524 hasConcept C2781372283 @default.
- W17295524 hasConcept C2908647359 @default.
- W17295524 hasConcept C55493867 @default.
- W17295524 hasConcept C555293320 @default.
- W17295524 hasConcept C55728118 @default.
- W17295524 hasConcept C71924100 @default.
- W17295524 hasConcept C99454951 @default.
- W17295524 hasConceptScore W17295524C104317684 @default.
- W17295524 hasConceptScore W17295524C104826730 @default.
- W17295524 hasConceptScore W17295524C109523444 @default.
- W17295524 hasConceptScore W17295524C126322002 @default.
- W17295524 hasConceptScore W17295524C127561419 @default.
- W17295524 hasConceptScore W17295524C134018914 @default.
- W17295524 hasConceptScore W17295524C144980905 @default.
- W17295524 hasConceptScore W17295524C149601957 @default.
- W17295524 hasConceptScore W17295524C170493617 @default.
- W17295524 hasConceptScore W17295524C181199279 @default.
- W17295524 hasConceptScore W17295524C185592680 @default.
- W17295524 hasConceptScore W17295524C2780268870 @default.
- W17295524 hasConceptScore W17295524C2781372283 @default.
- W17295524 hasConceptScore W17295524C2908647359 @default.
- W17295524 hasConceptScore W17295524C55493867 @default.
- W17295524 hasConceptScore W17295524C555293320 @default.
- W17295524 hasConceptScore W17295524C55728118 @default.
- W17295524 hasConceptScore W17295524C71924100 @default.
- W17295524 hasConceptScore W17295524C99454951 @default.
- W17295524 hasIssue "4" @default.
- W17295524 hasLocation W172955241 @default.
- W17295524 hasOpenAccess W17295524 @default.
- W17295524 hasPrimaryLocation W172955241 @default.
- W17295524 hasRelatedWork W1538958539 @default.
- W17295524 hasRelatedWork W1545831225 @default.
- W17295524 hasRelatedWork W17295524 @default.
- W17295524 hasRelatedWork W2008459374 @default.
- W17295524 hasRelatedWork W2012605290 @default.
- W17295524 hasRelatedWork W2021872466 @default.
- W17295524 hasRelatedWork W2066186705 @default.
- W17295524 hasRelatedWork W2074099073 @default.
- W17295524 hasRelatedWork W2273238577 @default.
- W17295524 hasRelatedWork W2310121990 @default.
- W17295524 hasVolume "12" @default.
- W17295524 isParatext "false" @default.
- W17295524 isRetracted "false" @default.
- W17295524 magId "17295524" @default.
- W17295524 workType "article" @default.