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• W1729732610 abstract "Inositol 1,4,5-trisphosphate (InsP3) constitutes a major intracellular second messenger that transduces many growth factor and neurotransmitter signals. InsP3 causes the release of Ca2+ from intracellular stores by binding to specific receptors that are coupled to Ca2+ channels. One such receptor from cerebellum has previously been extensively characterized. We have now determined the full structure of a second, novel InsP3 receptor which we refer to as type 2 InsP3 receptor as opposed to the cerebellar type 1 InsP3 receptor. The type 2 InsP3 receptor has the same general structural design as the cerebellar type 1 InsP3 receptor with which it shares 69% sequence identity. Expression of the amino-terminal 1078 amino acids of the type 2 receptor demonstrates high affinity binding of InsP3 to the type 2 receptor with a similar specificity but higher affinity than observed for the type 1 receptor. These results demonstrate the presence of several types of InsP3 receptor in brain and raise the possibility that intracellular Ca2+ signaling may involve multiple pathways with different regulatory properties dependent on different InsP3 receptors." @default.
• W1729732610 created "2016-06-24" @default.
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• W1729732610 date "1991-11-01" @default.
• W1729732610 modified "2023-10-15" @default.
• W1729732610 title "Structure of a novel InsP3 receptor." @default.
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• W1729732610 doi "https://doi.org/10.1002/j.1460-2075.1991.tb04882.x" @default.
• W1729732610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/453043" @default.
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