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- W172991566 abstract "This chapter examines the most recent molecular biological information related to inwardly rectifying K + channels in myocardium. K + channels play important roles in the formation of different phases of the cardiac action potential. Inwardly rectifying K + channels (Kir) include classical Kir channels (I K1 ), G-protein-activated muscarinic K + channels (K ACh ), Na + -activated K + channels (K Na ), and ATP sensitive K + channels (K ATP ). Kir channels play diverse functional roles, such as setting of the resting membrane potential near the K + equilibrium potential (I K1 channel), acetylcholine (Ach)-induced deceleration of the heart beat (K Ach channel), and metabolic impairment-induced shortening of the action potential (K ATP channel and possibly K Na channel). Kir channels are not regulated by the membrane potential, but by intracellular substances, such as polyamines and Mg 2+ ions. These substances block the outward-going K + currents through Kir channels above the K + equilibrium potential, resulting in the inwardly rectifying property. Another feature common to Kir channels is that the channel conductance increases as the concentration of extracellular K + increases. Also each Kir channel is regulated by intracellular specific ligands, G-protein (K ACh ), ATP (K ATP ), and Na + (K Na ), which are essential for their different functional roles." @default.
- W172991566 created "2016-06-24" @default.
- W172991566 creator A5051095566 @default.
- W172991566 creator A5061067071 @default.
- W172991566 creator A5084693611 @default.
- W172991566 date "2001-01-01" @default.
- W172991566 modified "2023-09-26" @default.
- W172991566 title "Inwardly-Rectifying K+ Channels in the Heart" @default.
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