FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1729930119> ?p ?o ?g. }

• W1729930119 endingPage "1047" @default.
• W1729930119 startingPage "1036" @default.
• W1729930119 abstract "The present study explores in vivo whether and how prostaglandin F(2alpha) (PGF(2alpha)), a membrane phospholipid hydrolysis product, causes neuronal death. The concentration of PGF(2alpha) measured by microdialysis sampling increased threefold immediately following impact injury to the rat spinal cord. Administration of PGF(2alpha) into the cord through a dialysis fiber caused significant cell loss, increased extracellular levels of hydroxyl radicals and malondialdehyde - an end product of membrane lipid peroxidation - to 3.3 and 2.3 times basal levels, respectively. This suggests that PGF(2alpha)-induced cell death is partly due to hydroxyl radical-triggered peroxidation. Generating hydroxyl radical by administering Fenton's reagents into the cord through the fibers significantly increased malondialdehyde production - the first direct in vivo evidence that hydroxyl radical triggers membrane lipid peroxidation. Methylprednisolone significantly reduced the release of PGF(2alpha) upon spinal cord injury and blocked PGF(2alpha)-induced hydroxyl radical and malondialdehyde production, but did not significantly reduce Fenton's reagent-induced malondialdehyde production, despite the production of more malondialdehyde by PGF(2alpha). This suggests that methylprednisolone may not directly scavenge hydroxyl radical, and that its 'antioxidant' effect is a consequence of blocking the pathways for producing toxic PGF(2alpha) and for PGF(2alpha)-induced hydroxyl radical formation, thereby reducing membrane lipid peroxidation." @default.
• W1729930119 created "2016-06-24" @default.
• W1729930119 creator A5029447773 @default.
• W1729930119 creator A5038259858 @default.
• W1729930119 creator A5049329745 @default.
• W1729930119 date "2001-12-20" @default.
• W1729930119 modified "2023-10-16" @default.
• W1729930119 title "Prostaglandin release by spinal cord injury mediates production of hydroxyl radical, malondialdehyde and cell death: a site of the neuroprotective action of methylprednisolone" @default.
• W1729930119 cites W11326691 @default.
• W1729930119 cites W11988665 @default.
• W1729930119 cites W1585029221 @default.
• W1729930119 cites W1593489888 @default.
• W1729930119 cites W1964491190 @default.
• W1729930119 cites W1966230878 @default.
• W1729930119 cites W1967757061 @default.
• W1729930119 cites W1969912167 @default.
• W1729930119 cites W1980839482 @default.
• W1729930119 cites W1981846207 @default.
• W1729930119 cites W1984202672 @default.
• W1729930119 cites W1985132050 @default.
• W1729930119 cites W1989329725 @default.
• W1729930119 cites W1989713074 @default.
• W1729930119 cites W1992229482 @default.
• W1729930119 cites W1993802713 @default.
• W1729930119 cites W1995387403 @default.
• W1729930119 cites W2002094235 @default.
• W1729930119 cites W2002769318 @default.
• W1729930119 cites W2009125386 @default.
• W1729930119 cites W2010283273 @default.
• W1729930119 cites W2014749152 @default.
• W1729930119 cites W2015031538 @default.
• W1729930119 cites W2016038775 @default.
• W1729930119 cites W2019403683 @default.
• W1729930119 cites W2020186980 @default.
• W1729930119 cites W2021789707 @default.
• W1729930119 cites W2026489163 @default.
• W1729930119 cites W2030676523 @default.
• W1729930119 cites W2035504416 @default.
• W1729930119 cites W2036663602 @default.
• W1729930119 cites W2037492324 @default.
• W1729930119 cites W2037671654 @default.
• W1729930119 cites W2039485608 @default.
• W1729930119 cites W2040472632 @default.
• W1729930119 cites W2042308433 @default.
• W1729930119 cites W2045257406 @default.
• W1729930119 cites W2053985129 @default.
• W1729930119 cites W2056843357 @default.
• W1729930119 cites W2063046332 @default.
• W1729930119 cites W2085864993 @default.
• W1729930119 cites W2087044616 @default.
• W1729930119 cites W2090544950 @default.
• W1729930119 cites W2095450169 @default.
• W1729930119 cites W2146412018 @default.
• W1729930119 cites W2146670425 @default.
• W1729930119 cites W2153288081 @default.
• W1729930119 cites W2154418626 @default.
• W1729930119 cites W2157882954 @default.
• W1729930119 cites W2159663717 @default.
• W1729930119 cites W2168460845 @default.
• W1729930119 cites W2328498688 @default.
• W1729930119 cites W2432127637 @default.
• W1729930119 cites W2797732082 @default.
• W1729930119 cites W292133527 @default.
• W1729930119 cites W4295334631 @default.
• W1729930119 doi "https://doi.org/10.1046/j.1471-4159.2001.00306.x" @default.
• W1729930119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11359869" @default.
• W1729930119 hasPublicationYear "2001" @default.
• W1729930119 type Work @default.
• W1729930119 sameAs 1729930119 @default.
• W1729930119 citedByCount "51" @default.
• W1729930119 countsByYear W17299301192013 @default.
• W1729930119 countsByYear W17299301192014 @default.
• W1729930119 countsByYear W17299301192015 @default.
• W1729930119 countsByYear W17299301192016 @default.
• W1729930119 countsByYear W17299301192018 @default.
• W1729930119 countsByYear W17299301192019 @default.
• W1729930119 countsByYear W17299301192022 @default.
• W1729930119 countsByYear W17299301192023 @default.
• W1729930119 crossrefType "journal-article" @default.
• W1729930119 hasAuthorship W1729930119A5029447773 @default.
• W1729930119 hasAuthorship W1729930119A5038259858 @default.
• W1729930119 hasAuthorship W1729930119A5049329745 @default.
• W1729930119 hasBestOaLocation W17299301191 @default.
• W1729930119 hasConcept C126322002 @default.
• W1729930119 hasConcept C185592680 @default.
• W1729930119 hasConcept C2776778087 @default.
• W1729930119 hasConcept C2778004101 @default.
• W1729930119 hasConcept C2778401633 @default.
• W1729930119 hasConcept C2780372218 @default.
• W1729930119 hasConcept C2780829032 @default.
• W1729930119 hasConcept C55493867 @default.
• W1729930119 hasConcept C71924100 @default.
• W1729930119 hasConcept C98274493 @default.
• W1729930119 hasConceptScore W1729930119C126322002 @default.
• W1729930119 hasConceptScore W1729930119C185592680 @default.
• W1729930119 hasConceptScore W1729930119C2776778087 @default.
• W1729930119 hasConceptScore W1729930119C2778004101 @default.
• W1729930119 hasConceptScore W1729930119C2778401633 @default.

• next