Matches in SemOpenAlex for { <https://semopenalex.org/work/W173000961> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W173000961 endingPage "9" @default.
- W173000961 startingPage "2195" @default.
- W173000961 abstract "To evaluate the responsiveness of measures of disability, discomfort, and disease process in rheumatoid arthritis (RA) clinical trials, when used as group summary variables and as variables of individual patient improvement.Disease outcome and process measures were assessed in 97 patients with RA of recent onset, who were participating in a prospective trial comparing the effectiveness of several drug treatment strategies. Measurements were done after 3 and 6 months of treatment. Group summary analysis was performed with tests of statistical significance of changes, and by calculating effect sizes (i.e., mean change in an endpoint divided by its standard deviation). Individual patient improvement was defined as improvement of > or = 33% compared to baseline, according to recommendations of the recently held Conference on Outcome Measures in Rheumatoid Arthritis Clinical Trials.Almost all mean group changes in endpoints were statistically significant (p < 0.001). Effect sizes and figures on individual patient improvement provided additional information: physical discomfort measures were rapidly responding measures that did not further improve after 3 months; disease process measures, joint count, erythrocyte sedimentation rate and C-reactive protein also responded quickly and kept improving up to 6 months; the disability measures were relatively unchanged at 3 months, and only the self-report questionnaire score showed considerable improvement at 6 months.Effect sizes and data on patients who showed clinical improvement in disease process or outcome measures offset the strongly significant p values of statistical tests for almost all endpoint measures. Although discomfort measures rapidly responded to therapy, disability and disease process measures may not reach optimal improvement within 6 months." @default.
- W173000961 created "2016-06-24" @default.
- W173000961 creator A5024475887 @default.
- W173000961 creator A5025655981 @default.
- W173000961 creator A5059638236 @default.
- W173000961 creator A5086841743 @default.
- W173000961 date "1994-12-01" @default.
- W173000961 modified "2023-09-26" @default.
- W173000961 title "Endpoint measures in rheumatoid arthritis clinical trials: group summary and individual patient analysis." @default.
- W173000961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7699618" @default.
- W173000961 hasPublicationYear "1994" @default.
- W173000961 type Work @default.
- W173000961 sameAs 173000961 @default.
- W173000961 citedByCount "8" @default.
- W173000961 crossrefType "journal-article" @default.
- W173000961 hasAuthorship W173000961A5024475887 @default.
- W173000961 hasAuthorship W173000961A5025655981 @default.
- W173000961 hasAuthorship W173000961A5059638236 @default.
- W173000961 hasAuthorship W173000961A5086841743 @default.
- W173000961 hasConcept C126322002 @default.
- W173000961 hasConcept C159110408 @default.
- W173000961 hasConcept C1862650 @default.
- W173000961 hasConcept C203092338 @default.
- W173000961 hasConcept C2777575956 @default.
- W173000961 hasConcept C2778143017 @default.
- W173000961 hasConcept C2779517570 @default.
- W173000961 hasConcept C2779951463 @default.
- W173000961 hasConcept C535046627 @default.
- W173000961 hasConcept C71924100 @default.
- W173000961 hasConceptScore W173000961C126322002 @default.
- W173000961 hasConceptScore W173000961C159110408 @default.
- W173000961 hasConceptScore W173000961C1862650 @default.
- W173000961 hasConceptScore W173000961C203092338 @default.
- W173000961 hasConceptScore W173000961C2777575956 @default.
- W173000961 hasConceptScore W173000961C2778143017 @default.
- W173000961 hasConceptScore W173000961C2779517570 @default.
- W173000961 hasConceptScore W173000961C2779951463 @default.
- W173000961 hasConceptScore W173000961C535046627 @default.
- W173000961 hasConceptScore W173000961C71924100 @default.
- W173000961 hasIssue "12" @default.
- W173000961 hasLocation W1730009611 @default.
- W173000961 hasOpenAccess W173000961 @default.
- W173000961 hasPrimaryLocation W1730009611 @default.
- W173000961 hasRelatedWork W173000961 @default.
- W173000961 hasRelatedWork W2023542962 @default.
- W173000961 hasRelatedWork W2047023259 @default.
- W173000961 hasRelatedWork W2059378490 @default.
- W173000961 hasRelatedWork W2101275051 @default.
- W173000961 hasRelatedWork W2127088940 @default.
- W173000961 hasRelatedWork W2169501120 @default.
- W173000961 hasRelatedWork W2320240246 @default.
- W173000961 hasRelatedWork W2765367506 @default.
- W173000961 hasRelatedWork W4205525658 @default.
- W173000961 hasVolume "21" @default.
- W173000961 isParatext "false" @default.
- W173000961 isRetracted "false" @default.
- W173000961 magId "173000961" @default.
- W173000961 workType "article" @default.