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- W1730510779 abstract "Abstract Background The relative safety and efficacy of drug‐eluting stents ( DES ) versus bare‐metal stents ( BMS ) in patients with calcified coronary lesions is still debated. Aims To evaluate clinical outcome of DES versus BMS in patients with calcified coronary lesions using a meta‐analysis of the current literature. Methods We performed a systematic literature search using M edline, E mbase, C ochrane and several other databases. Randomised controlled trials, prospective and retrospective cohort studies with a mean follow‐up period >6 months were included. Primary efficacy was target lesions revascularisation ( TLR ) and primary end‐point for safety was stent thrombosis. Secondary end‐points were cardiac death and recurrent myocardial infarction ( MI ). Results Five trials were included in the meta‐analysis, including 2440 patients (1230 in the DES group, 1210 in the BMS group). TLR was significantly lower in patients treated with DES as compared with patients treated with BMS (8.5% vs 16.0%; odds ratio ( OR ) = 0.50; 95% confidence interval ( CI ) 0.38–0.65; P < 0.00001). There were no significant differences in the incidence of stent thrombosis (0.9% vs 0.3%; OR = 2.01; 95% CI 0.34–11.88; P = 0.44), cardiac death (3.3% vs 4.2%; OR = 0.81; 95% CI 0.50–1.30; P = 0.38) and recurrent MI (5.0% vs 5.2%; OR = 0.99; 95% CI , 0.66–1.49; P = 0.97) between the two groups. Subgroup analysis by the sample size and follow‐up duration showed that the associations were similar between DES versus BMS . Conclusions DES significantly reduces TLR rates as compared with BMS in patients with calcified coronary lesions, with non‐significant differences in terms of stent thrombosis, cardiac death and MI ." @default.
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- W1730510779 date "2015-02-01" @default.
- W1730510779 modified "2023-09-27" @default.
- W1730510779 title "Clinical outcome of drug-eluting versus bare-metal stents in patients with calcified coronary lesions: a meta-analysis" @default.
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- W1730510779 doi "https://doi.org/10.1111/imj.12622" @default.
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