FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1730875209> ?p ?o ?g. }

• W1730875209 endingPage "1098" @default.
• W1730875209 startingPage "1092" @default.
• W1730875209 abstract "Objective. Opioids have relieved more human suffering than any other medication, but their use is still fraught with significant concerns of misuse, abuse, and addiction. This theoretical article explores the hypothesis that opioid misuse in the context of pain management produces a hypersensitivity to emotional distress, termed hyperkatifeia. Results. In the misuse of opioids, neural substrates that mediate positive emotional states (brain reward systems) are compromised, and substrates mediating negative emotional states (brain stress systems) are enhanced. A reflection and early marker of such a nonhomeostatic state may be the development of opioid-induced hyperkatifeia, defined as the increased intensity of the constellation of negative emotional/motivational symptoms and signs observed during withdrawal from drugs of abuse (derived from the Greek “katifeia” for dejection or negative emotional state) and is most likely to occur in subjects in whom the opioid produces a break with homeostasis and less likely to occur when the opioid is restoring homeostasis, such as in effective pain treatment. When the opioid appropriately relieves pain, opponent processes are not engaged. However, if the opioid is administered in excess of need because of overdose, pharmacokinetic variables, or treating an individual without pain, then the body will react to that perturbation by engaging opponent processes in the domains of both pain (hyperalgesia) and negative emotional states (hyperkatifeia). Conclusions. Repeated engagement of opponent processes without time for the brain's emotional systems to reestablish homeostasis will further drive changes in emotional processes that may produce opioid abuse or addiction, particularly in individuals with genetic or environmental vulnerability." @default.
• W1730875209 created "2016-06-24" @default.
• W1730875209 creator A5044506739 @default.
• W1730875209 creator A5054441496 @default.
• W1730875209 creator A5075246876 @default.
• W1730875209 date "2010-07-01" @default.
• W1730875209 modified "2023-10-16" @default.
• W1730875209 title "Opioids, Pain, the Brain, and Hyperkatifeia: A Framework for the Rational Use of Opioids for Pain" @default.
• W1730875209 cites W1606572296 @default.
• W1730875209 cites W1771301420 @default.
• W1730875209 cites W1968047901 @default.
• W1730875209 cites W1969384722 @default.
• W1730875209 cites W1978762354 @default.
• W1730875209 cites W1984109440 @default.
• W1730875209 cites W1991882455 @default.
• W1730875209 cites W1996834041 @default.
• W1730875209 cites W2005703418 @default.
• W1730875209 cites W2007791604 @default.
• W1730875209 cites W2024783852 @default.
• W1730875209 cites W2033641234 @default.
• W1730875209 cites W2042817255 @default.
• W1730875209 cites W2051735856 @default.
• W1730875209 cites W2080800530 @default.
• W1730875209 cites W2090931660 @default.
• W1730875209 cites W2096688894 @default.
• W1730875209 cites W2128036760 @default.
• W1730875209 cites W2128551864 @default.
• W1730875209 cites W2158624732 @default.
• W1730875209 cites W2317740358 @default.
• W1730875209 cites W2402009018 @default.
• W1730875209 cites W4241849749 @default.
• W1730875209 doi "https://doi.org/10.1111/j.1526-4637.2010.00881.x" @default.
• W1730875209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2907890" @default.
• W1730875209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20545871" @default.
• W1730875209 hasPublicationYear "2010" @default.
• W1730875209 type Work @default.
• W1730875209 sameAs 1730875209 @default.
• W1730875209 citedByCount "157" @default.
• W1730875209 countsByYear W17308752092012 @default.
• W1730875209 countsByYear W17308752092013 @default.
• W1730875209 countsByYear W17308752092014 @default.
• W1730875209 countsByYear W17308752092015 @default.
• W1730875209 countsByYear W17308752092016 @default.
• W1730875209 countsByYear W17308752092017 @default.
• W1730875209 countsByYear W17308752092018 @default.
• W1730875209 countsByYear W17308752092019 @default.
• W1730875209 countsByYear W17308752092020 @default.
• W1730875209 countsByYear W17308752092021 @default.
• W1730875209 countsByYear W17308752092022 @default.
• W1730875209 countsByYear W17308752092023 @default.
• W1730875209 crossrefType "journal-article" @default.
• W1730875209 hasAuthorship W1730875209A5044506739 @default.
• W1730875209 hasAuthorship W1730875209A5054441496 @default.
• W1730875209 hasAuthorship W1730875209A5075246876 @default.
• W1730875209 hasBestOaLocation W17308752091 @default.
• W1730875209 hasConcept C118552586 @default.
• W1730875209 hasConcept C125439840 @default.
• W1730875209 hasConcept C126322002 @default.
• W1730875209 hasConcept C151730666 @default.
• W1730875209 hasConcept C15490471 @default.
• W1730875209 hasConcept C15744967 @default.
• W1730875209 hasConcept C170493617 @default.
• W1730875209 hasConcept C2779245659 @default.
• W1730875209 hasConcept C2779343474 @default.
• W1730875209 hasConcept C2781063702 @default.
• W1730875209 hasConcept C2781118164 @default.
• W1730875209 hasConcept C48856860 @default.
• W1730875209 hasConcept C71924100 @default.
• W1730875209 hasConcept C86803240 @default.
• W1730875209 hasConcept C88016717 @default.
• W1730875209 hasConceptScore W1730875209C118552586 @default.
• W1730875209 hasConceptScore W1730875209C125439840 @default.
• W1730875209 hasConceptScore W1730875209C126322002 @default.
• W1730875209 hasConceptScore W1730875209C151730666 @default.
• W1730875209 hasConceptScore W1730875209C15490471 @default.
• W1730875209 hasConceptScore W1730875209C15744967 @default.
• W1730875209 hasConceptScore W1730875209C170493617 @default.
• W1730875209 hasConceptScore W1730875209C2779245659 @default.
• W1730875209 hasConceptScore W1730875209C2779343474 @default.
• W1730875209 hasConceptScore W1730875209C2781063702 @default.
• W1730875209 hasConceptScore W1730875209C2781118164 @default.
• W1730875209 hasConceptScore W1730875209C48856860 @default.
• W1730875209 hasConceptScore W1730875209C71924100 @default.
• W1730875209 hasConceptScore W1730875209C86803240 @default.
• W1730875209 hasConceptScore W1730875209C88016717 @default.
• W1730875209 hasIssue "7" @default.
• W1730875209 hasLocation W17308752091 @default.
• W1730875209 hasLocation W17308752092 @default.
• W1730875209 hasLocation W17308752093 @default.
• W1730875209 hasLocation W17308752094 @default.
• W1730875209 hasOpenAccess W1730875209 @default.
• W1730875209 hasPrimaryLocation W17308752091 @default.
• W1730875209 hasRelatedWork W1965248892 @default.
• W1730875209 hasRelatedWork W2083356101 @default.
• W1730875209 hasRelatedWork W2097450926 @default.
• W1730875209 hasRelatedWork W2127947295 @default.
• W1730875209 hasRelatedWork W2328497181 @default.
• W1730875209 hasRelatedWork W2548321923 @default.

• next