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• W173100983 endingPage "246" @default.
• W173100983 startingPage "221" @default.
• W173100983 abstract "The most commonly used cell-penetrating peptides (CPPs): Tat, oligoarginine, and transportan, have all been demonstrated to facilitate the entry of protein/peptide cargoes into cells both in vitro and in vivo. In cellular systems, transportan has displayed greater internalization properties than the aforementioned arginine-rich CPPs and their uptake efficiencies can be depicted as follows: transportan > oligoarginine > Tat peptide. When picking the “right” CPP sequence for cargo delivery, both of these aspects need to be considered, and when lower concentrations are used, the transportan or oligoarginine should be preferred. In vivo, however, the uptake efficiency, specificity, and toxicity have not been extensively studied for the different CPPs. Nevertheless, it is evident that for targeted delivery, some extra motifs need to be added to the CPP sequence. A rather promising aspect for CPP-mediated delivery of peptides/proteins is that transcytosis in endothelial cells requires caveolin. Several CPPs, but especially transportan, exploit the caveolin pathway for cell entry, possibly giving transportan a beneficial “edge” in vivo. Despite the number of obstacles and pending challenges still faced today, the growing number of examples of in vivo delivery, Tat-HSP70 for neuronal rescue and Tat-Bcl-x(L) for improved neuronal precursor cell survival, confirm that the problems can be overcome in one way or another." @default.
• W173100983 created "2016-06-24" @default.
• W173100983 creator A5005113844 @default.
• W173100983 creator A5013588675 @default.
• W173100983 date "2011-01-01" @default.
• W173100983 modified "2023-09-23" @default.
• W173100983 title "Peptide and Protein Delivery with Cell-penetrating Peptides" @default.
• W173100983 cites W1574601702 @default.
• W173100983 cites W1575798288 @default.
• W173100983 cites W1584683177 @default.
• W173100983 cites W1600222764 @default.
• W173100983 cites W1963662573 @default.
• W173100983 cites W1966023540 @default.
• W173100983 cites W1966434325 @default.
• W173100983 cites W1967117930 @default.
• W173100983 cites W1969496633 @default.
• W173100983 cites W1969583827 @default.
• W173100983 cites W1970898997 @default.
• W173100983 cites W1971919281 @default.
• W173100983 cites W1972711580 @default.
• W173100983 cites W1972930778 @default.
• W173100983 cites W1975148998 @default.
• W173100983 cites W1976223354 @default.
• W173100983 cites W1976822357 @default.
• W173100983 cites W1978498174 @default.
• W173100983 cites W1980837484 @default.
• W173100983 cites W1983138928 @default.
• W173100983 cites W1983679894 @default.
• W173100983 cites W1985113094 @default.
• W173100983 cites W1985719826 @default.
• W173100983 cites W1989855380 @default.
• W173100983 cites W1991419088 @default.
• W173100983 cites W1992289979 @default.
• W173100983 cites W1992337937 @default.
• W173100983 cites W1996461253 @default.
• W173100983 cites W2001038738 @default.
• W173100983 cites W2001582257 @default.
• W173100983 cites W2001674490 @default.
• W173100983 cites W2002292653 @default.
• W173100983 cites W2002300978 @default.
• W173100983 cites W2002410880 @default.
• W173100983 cites W2002591579 @default.
• W173100983 cites W2004739654 @default.
• W173100983 cites W2005454916 @default.
• W173100983 cites W2006795600 @default.
• W173100983 cites W2007308838 @default.
• W173100983 cites W2007836674 @default.
• W173100983 cites W2008813620 @default.
• W173100983 cites W2009836750 @default.
• W173100983 cites W2010659535 @default.
• W173100983 cites W2011409735 @default.
• W173100983 cites W2013760630 @default.
• W173100983 cites W2014721876 @default.
• W173100983 cites W2015120929 @default.
• W173100983 cites W2017201573 @default.
• W173100983 cites W2017653272 @default.
• W173100983 cites W2018369626 @default.
• W173100983 cites W2020295926 @default.
• W173100983 cites W2022996046 @default.
• W173100983 cites W2026405782 @default.
• W173100983 cites W2028035233 @default.
• W173100983 cites W2031064824 @default.
• W173100983 cites W2033157388 @default.
• W173100983 cites W2033459508 @default.
• W173100983 cites W2037165833 @default.
• W173100983 cites W2038720675 @default.
• W173100983 cites W2039242651 @default.
• W173100983 cites W2039702376 @default.
• W173100983 cites W2039949937 @default.
• W173100983 cites W2040837189 @default.
• W173100983 cites W2042143995 @default.
• W173100983 cites W2045062911 @default.
• W173100983 cites W2046314109 @default.
• W173100983 cites W2047836608 @default.
• W173100983 cites W2050291058 @default.
• W173100983 cites W2052325529 @default.
• W173100983 cites W2052949014 @default.
• W173100983 cites W2055978208 @default.
• W173100983 cites W2057486197 @default.
• W173100983 cites W2057870351 @default.
• W173100983 cites W2058907087 @default.
• W173100983 cites W2059995799 @default.
• W173100983 cites W2060619977 @default.
• W173100983 cites W2060996573 @default.
• W173100983 cites W2061476447 @default.
• W173100983 cites W2062253976 @default.
• W173100983 cites W2062950731 @default.
• W173100983 cites W2063196014 @default.
• W173100983 cites W2064242356 @default.
• W173100983 cites W2064634662 @default.
• W173100983 cites W2064761355 @default.
• W173100983 cites W2066331352 @default.
• W173100983 cites W2066778206 @default.
• W173100983 cites W2066936722 @default.
• W173100983 cites W2067481068 @default.
• W173100983 cites W2073199563 @default.
• W173100983 cites W2074721095 @default.
• W173100983 cites W2076859770 @default.

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