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- W173105440 abstract "Objective To investigate the effect of low molecular weight potassium alginate (L-PA) on blood pressures in spontaneously hypertensive rats (SHRs) and its pharmacokinetics characteristics in mice. Methods The systolic blood pressure (SBP) was measured by tail-cuff method in conscious SHRs. Forty rats were randomly assigned to the following five groups:control,hydrochlorothiazide (HCT,6.25 mg/kg),L-PA in low,middle or high dose groups (100,250,500 mg/kg). SHRs were intragastrically (i.g.) administrated once daily for 28 days. The SBP was measured once weekly during drug treatment,and 3 and 6 days after drug with drawal. KM mice were i.g. administered with 100 mg/kg (74 MBq/kg) of 3H-L-PA. Ten μl blood samples were obtained from the tail vein at 2,5,10,20,30 min and 1,2,4,6,12,24,48,72,96,120 or 144 h after drug administration for measuring radioactivities. Pharmacokinetics parameters of the oral administration of L-PA were analysed with DAS 2.0 software. Results Twenty-one or 28 days after administration,the rats in the groups treated with HCT or L-PA at 100,250 or 500 mg/kg had a significant decrease in SBP (P0.01 vs control group). Three or 6 days after drug withdrawal,the antihypertensive effect of HCT disappeared (P0.05),whereas the rats treated with 250 or 500 mg/kg L-PA still had lower SBP than the controls (P0.01). The L-PA at a dose of 100 mg/kg also led to a significant decrease in SBP 3 days after drug withdrawal (P0.05). The pharmacokinetics of L-PA (i.g.) was consistent with a two-compartment model,with 2.76 h of absorption half-life (t1/2Ka),42.30 h of distributional half-life (t1/2α),42.31 h of elimination half-life (t1/2β),and 36.28 h of terminal phase elimination half-life (t1/2z). Conclusion Oral administration of L-PA has significant anti-hypertensive effect,which can be maintained to 6 days after drug withdrawal. The sustaining anti-hypertensive effect of L-PA is probably associated with its slow elimination in vivo." @default.
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- W173105440 date "2009-07-01" @default.
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- W173105440 title "Antihypertensive effect and pharmacokinetics of low molecular mass potassium alginate" @default.
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