FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1731269130> ?p ?o ?g. }

• W1731269130 endingPage "104" @default.
• W1731269130 startingPage "97" @default.
• W1731269130 abstract "Summary Abnormalities in the p53 gene are regarded as the most consistent of the genetic abnormalities associated with oral squamous‐cell carcinoma. Two related members of the p53 gene family, p73 and p63 , have shown remarkable structural similarity to p53 , suggesting possible functional and biological interactions. The purpose of this study was to investigate the differential expression of p73 , p63 and p53 genes for DMBA‐induced hamster buccal‐pouch squamous‐cell carcinoma. Immunohistochemical analysis for protein expression and reverse transcriptase‐polymerase chain reaction (RT‐PCR) for mRNA expression were performed for 40 samples of hamster buccal pouches, the total being separated into one experimental group (15‐week DMBA‐treated; 20 animals) and two control groups (untreated and mineral oil‐treated; 10 animals each). Using immunohistochemical techniques, nuclear staining of p53 and p73 proteins was detected in a subset of hamster buccal‐pouch tissue specimens treated with DMBA for a period of 15 weeks, whereas p63 proteins were noted for all of the 20 hamster buccal‐pouch tissue specimens treated with DMBA for 15 weeks as well as for all of the untreated and mineral oil‐treated hamster buccal‐pouch tissue specimens. Differential expression of p63, p73 and p53 protein for the experimental group was as follows: p63+/p73+/p53+ ( n = 14; 70%); p63+/p73+/p53– ( n = 2; 10%); p63+/p73–/p53– ( n = 4; 20%) and p63+/p73–/p53– (untreated [ n = 10] and mineral oil‐treated mucosa [ n = 10]; 100% each). Upon RT‐PCR, ΔNp63mRNA was detected within all of the 20 hamster buccal‐pouch tissue specimens treated with DMBA for 15 weeks, whereas expression of TAp63 was not detected. Furthermore, p73 mRNA was identified for 16 of the hamster buccal‐pouch tissue specimens treated with DMBA for 15 weeks, whereas p53 mRNA was noted for 14 15‐week DMBA‐treated pouches. The proportional (percentage) expression of ΔNp63, p73 and p53 mRNA for the hamster buccal‐pouch tissue specimens treated with DMBA for 15 weeks was noted to be consistent with the findings using immunohistochemical techniques. A significant correlation between p53, p63 and p73 expression (protein and mRNA) was demonstrated for the hamster buccal‐pouch carcinoma samples. Our results indicate that both p73 and p63 may be involved in the development of chemically induced hamster buccal‐pouch carcinomas, perhaps in concert with p53." @default.
• W1731269130 created "2016-06-24" @default.
• W1731269130 creator A5009860981 @default.
• W1731269130 creator A5027744020 @default.
• W1731269130 creator A5069804526 @default.
• W1731269130 date "2004-04-01" @default.
• W1731269130 modified "2023-10-15" @default.
• W1731269130 title "Differential expression of p53, p63 and p73 protein and mRNA for DMBA-induced hamster buccal-pouch squamous-cell carcinomas" @default.
• W1731269130 cites W1482923899 @default.
• W1731269130 cites W1520122908 @default.
• W1731269130 cites W1531240647 @default.
• W1731269130 cites W1562311274 @default.
• W1731269130 cites W1579239145 @default.
• W1731269130 cites W1675096266 @default.
• W1731269130 cites W1965395825 @default.
• W1731269130 cites W1979082790 @default.
• W1731269130 cites W1982763025 @default.
• W1731269130 cites W1985064409 @default.
• W1731269130 cites W1987026408 @default.
• W1731269130 cites W1993970552 @default.
• W1731269130 cites W2010181731 @default.
• W1731269130 cites W2010421388 @default.
• W1731269130 cites W2014938226 @default.
• W1731269130 cites W2026070406 @default.
• W1731269130 cites W2062364714 @default.
• W1731269130 cites W2067791819 @default.
• W1731269130 cites W2069357145 @default.
• W1731269130 cites W2076118650 @default.
• W1731269130 cites W2082180646 @default.
• W1731269130 cites W2090494026 @default.
• W1731269130 cites W2095588631 @default.
• W1731269130 cites W2096428903 @default.
• W1731269130 cites W2109948466 @default.
• W1731269130 cites W2114785892 @default.
• W1731269130 cites W2118102989 @default.
• W1731269130 cites W2128793659 @default.
• W1731269130 cites W2134812217 @default.
• W1731269130 cites W2134906851 @default.
• W1731269130 cites W2135927454 @default.
• W1731269130 cites W2149008645 @default.
• W1731269130 cites W2149287328 @default.
• W1731269130 cites W2165454946 @default.
• W1731269130 cites W2169752763 @default.
• W1731269130 cites W2468470429 @default.
• W1731269130 cites W4256129558 @default.
• W1731269130 cites W4294216491 @default.
• W1731269130 doi "https://doi.org/10.1111/j.0959-9673.2004.0374.x" @default.
• W1731269130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2517460" @default.
• W1731269130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15154915" @default.
• W1731269130 hasPublicationYear "2004" @default.
• W1731269130 type Work @default.
• W1731269130 sameAs 1731269130 @default.
• W1731269130 citedByCount "19" @default.
• W1731269130 countsByYear W17312691302013 @default.
• W1731269130 countsByYear W17312691302014 @default.
• W1731269130 countsByYear W17312691302016 @default.
• W1731269130 countsByYear W17312691302017 @default.
• W1731269130 countsByYear W17312691302023 @default.
• W1731269130 crossrefType "journal-article" @default.
• W1731269130 hasAuthorship W1731269130A5009860981 @default.
• W1731269130 hasAuthorship W1731269130A5027744020 @default.
• W1731269130 hasAuthorship W1731269130A5069804526 @default.
• W1731269130 hasBestOaLocation W17312691302 @default.
• W1731269130 hasConcept C104317684 @default.
• W1731269130 hasConcept C105702510 @default.
• W1731269130 hasConcept C142724271 @default.
• W1731269130 hasConcept C150194340 @default.
• W1731269130 hasConcept C153911025 @default.
• W1731269130 hasConcept C195735259 @default.
• W1731269130 hasConcept C203014093 @default.
• W1731269130 hasConcept C204232928 @default.
• W1731269130 hasConcept C2776657240 @default.
• W1731269130 hasConcept C2777546739 @default.
• W1731269130 hasConcept C2778575167 @default.
• W1731269130 hasConcept C2778938436 @default.
• W1731269130 hasConcept C2780101441 @default.
• W1731269130 hasConcept C2994460389 @default.
• W1731269130 hasConcept C34439696 @default.
• W1731269130 hasConcept C54355233 @default.
• W1731269130 hasConcept C55493867 @default.
• W1731269130 hasConcept C555283112 @default.
• W1731269130 hasConcept C60644358 @default.
• W1731269130 hasConcept C71924100 @default.
• W1731269130 hasConcept C86803240 @default.
• W1731269130 hasConceptScore W1731269130C104317684 @default.
• W1731269130 hasConceptScore W1731269130C105702510 @default.
• W1731269130 hasConceptScore W1731269130C142724271 @default.
• W1731269130 hasConceptScore W1731269130C150194340 @default.
• W1731269130 hasConceptScore W1731269130C153911025 @default.
• W1731269130 hasConceptScore W1731269130C195735259 @default.
• W1731269130 hasConceptScore W1731269130C203014093 @default.
• W1731269130 hasConceptScore W1731269130C204232928 @default.
• W1731269130 hasConceptScore W1731269130C2776657240 @default.
• W1731269130 hasConceptScore W1731269130C2777546739 @default.
• W1731269130 hasConceptScore W1731269130C2778575167 @default.
• W1731269130 hasConceptScore W1731269130C2778938436 @default.
• W1731269130 hasConceptScore W1731269130C2780101441 @default.
• W1731269130 hasConceptScore W1731269130C2994460389 @default.

• next