Matches in SemOpenAlex for { <https://semopenalex.org/work/W1731544355> ?p ?o ?g. }
- W1731544355 endingPage "1239" @default.
- W1731544355 startingPage "1232" @default.
- W1731544355 abstract "To better understand the ischemic-hypoxia-induced fracture healing impairment, we determined in this study the microRNA-210 expression in broken bone specimens and in osteoblasts under hypoxia and then determined the influence of microRNA-210 overexpression on the osteoblast cell proliferation and apoptosis. Results demonstrated that microRNA-210 expression was upregulated with an association with HIF-1α overexpression in clinical human catagmatic tissues and was upregulated HIF-1α-dependently in response to hypoxia in osteoblast MG-63 cells. CCK-8 assay indicated that microRNA-210 upregulation by microRNA-210 mimics reduced the chemotherapeutic 5-FU-induced osteoblast cell death, and colony formation assay demonstrated that microRNA-210 mimics promoted osteoblast cells growth. Moreover, the microRNA-210 mimics transfection inhibited the hypoxia-induced MG-63 cell apoptosis via inhibiting the activation of caspase 3 and caspase 9. Therefore, our research indicated a protective role of microRNA-210 in response to hypoxia. And microRNA-210 might serve as a protective role in bone fracture healing." @default.
- W1731544355 created "2016-06-24" @default.
- W1731544355 creator A5021306721 @default.
- W1731544355 creator A5046485480 @default.
- W1731544355 date "2015-08-03" @default.
- W1731544355 modified "2023-10-05" @default.
- W1731544355 title "HIF-1α-induced microRNA-210 reduces hypoxia-induced osteoblast MG-63 cell apoptosis" @default.
- W1731544355 cites W1543879113 @default.
- W1731544355 cites W1903252887 @default.
- W1731544355 cites W1970278573 @default.
- W1731544355 cites W1982861439 @default.
- W1731544355 cites W1988377666 @default.
- W1731544355 cites W1993324234 @default.
- W1731544355 cites W1996134770 @default.
- W1731544355 cites W2002394482 @default.
- W1731544355 cites W2005612470 @default.
- W1731544355 cites W2011653215 @default.
- W1731544355 cites W2024988321 @default.
- W1731544355 cites W2025138472 @default.
- W1731544355 cites W2039237627 @default.
- W1731544355 cites W2040147525 @default.
- W1731544355 cites W2044662583 @default.
- W1731544355 cites W2050005762 @default.
- W1731544355 cites W2050572533 @default.
- W1731544355 cites W2060959662 @default.
- W1731544355 cites W2066746047 @default.
- W1731544355 cites W2074629894 @default.
- W1731544355 cites W2081134904 @default.
- W1731544355 cites W2082018404 @default.
- W1731544355 cites W2086809547 @default.
- W1731544355 cites W2087604383 @default.
- W1731544355 cites W2089125941 @default.
- W1731544355 cites W2093281361 @default.
- W1731544355 cites W2093878343 @default.
- W1731544355 cites W2095004208 @default.
- W1731544355 cites W2097785842 @default.
- W1731544355 cites W2107277218 @default.
- W1731544355 cites W2109734397 @default.
- W1731544355 cites W2111316413 @default.
- W1731544355 cites W2115394717 @default.
- W1731544355 cites W2116000203 @default.
- W1731544355 cites W2121164913 @default.
- W1731544355 cites W2130335274 @default.
- W1731544355 cites W2130542771 @default.
- W1731544355 cites W2134189716 @default.
- W1731544355 cites W2149476024 @default.
- W1731544355 cites W2152121980 @default.
- W1731544355 cites W2152395959 @default.
- W1731544355 cites W2160889581 @default.
- W1731544355 cites W2162674813 @default.
- W1731544355 cites W2167959848 @default.
- W1731544355 cites W2168783417 @default.
- W1731544355 cites W4232230324 @default.
- W1731544355 cites W4236708194 @default.
- W1731544355 doi "https://doi.org/10.1080/09168451.2014.1003128" @default.
- W1731544355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26037388" @default.
- W1731544355 hasPublicationYear "2015" @default.
- W1731544355 type Work @default.
- W1731544355 sameAs 1731544355 @default.
- W1731544355 citedByCount "11" @default.
- W1731544355 countsByYear W17315443552016 @default.
- W1731544355 countsByYear W17315443552018 @default.
- W1731544355 countsByYear W17315443552020 @default.
- W1731544355 countsByYear W17315443552022 @default.
- W1731544355 countsByYear W17315443552023 @default.
- W1731544355 crossrefType "journal-article" @default.
- W1731544355 hasAuthorship W1731544355A5021306721 @default.
- W1731544355 hasAuthorship W1731544355A5046485480 @default.
- W1731544355 hasBestOaLocation W17315443551 @default.
- W1731544355 hasConcept C104317684 @default.
- W1731544355 hasConcept C127561419 @default.
- W1731544355 hasConcept C145059251 @default.
- W1731544355 hasConcept C1491633281 @default.
- W1731544355 hasConcept C178790620 @default.
- W1731544355 hasConcept C185592680 @default.
- W1731544355 hasConcept C190283241 @default.
- W1731544355 hasConcept C202751555 @default.
- W1731544355 hasConcept C2778260815 @default.
- W1731544355 hasConcept C31573885 @default.
- W1731544355 hasConcept C502942594 @default.
- W1731544355 hasConcept C540031477 @default.
- W1731544355 hasConcept C54009773 @default.
- W1731544355 hasConcept C54355233 @default.
- W1731544355 hasConcept C55493867 @default.
- W1731544355 hasConcept C62112901 @default.
- W1731544355 hasConcept C7836513 @default.
- W1731544355 hasConcept C81885089 @default.
- W1731544355 hasConcept C86803240 @default.
- W1731544355 hasConcept C95444343 @default.
- W1731544355 hasConceptScore W1731544355C104317684 @default.
- W1731544355 hasConceptScore W1731544355C127561419 @default.
- W1731544355 hasConceptScore W1731544355C145059251 @default.
- W1731544355 hasConceptScore W1731544355C1491633281 @default.
- W1731544355 hasConceptScore W1731544355C178790620 @default.
- W1731544355 hasConceptScore W1731544355C185592680 @default.
- W1731544355 hasConceptScore W1731544355C190283241 @default.
- W1731544355 hasConceptScore W1731544355C202751555 @default.
- W1731544355 hasConceptScore W1731544355C2778260815 @default.