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- W173208372 abstract "(Background) Matrix metalloproteinases-7 (MMP-7), one of an extracellular matrixdegrading metalloproteinase, play an important role tumor invasion and metastasis. We investigated localization, biochemical characterization and mRNA expression of MMP-7 in prostate tissues.(Methods) Immunohistochemical method, SDS-polyacrylamide gel electrophoresis and northern blot analysis were performed using tissues of prostatic cancer, BPH and normal prostate.(Results) A latent proenzyme with Mr28, 000 of MMP-7 was detected in the ductal epithelial cells of BPH and in the cytoplasm of cancer cell of the prostate. The ratio of mRNA expression in MMP-7/β-actin was significantly higher in the tissue of the invasive prostatic cancer than those of normal prostate and BPH in northern blot analysis.(Conclusions) these results suggest that MMP-7 may participate in the function of exocrine gland of normal prostate by preventing glandular obstruction and may play a role in invasion and metastasis of prostatic cancer." @default.
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- W173208372 date "1997-01-01" @default.
- W173208372 modified "2023-09-25" @default.
- W173208372 title "LOCALIZATION AND EXPRESSION OF MATRIX METALLOPROTEINASE-7 IN HUMAN PROSTATE" @default.
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- W173208372 doi "https://doi.org/10.5980/jpnjurol1989.88.852" @default.
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