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- W17332004 endingPage "665" @default.
- W17332004 startingPage "657" @default.
- W17332004 abstract "There is increasing epidemiological evidence in humans which associates low birthweight with later metabolic disorders, including insulin resistance and glucose intolerance. There is evidence that nutritional and hormonal factors (e.g. maternal protein restriction, exposure to excess maternal glucocorticoids) markedly influence intra-uterine growth and development. A picture is also emerging of the biochemical and physiological mechanisms that may underlie these effects. This review focuses on recent research directed towards understanding the molecular basis of the relationship between indices of poor early growth and the subsequent development of glucose intolerance and Type 2 diabetes mellitus using animal models that attempt to recreate the process of programming via an adverse intra-uterine or neonatal environment. Emphasis is on the chain of events and potential mechanisms by which adverse adaptations affect pancreatic-beta-cell insulin secretion and the sensitivity to insulin of key metabolic processes, including hepatic glucose production, skeletal-muscle glucose disposal and adipose-tissue lipolysis. Unravelling the molecular details involved in metabolic programming may provide new insights into the pathogenesis of impaired glucoregulation and Type 2 diabetes." @default.
- W17332004 created "2016-06-24" @default.
- W17332004 creator A5034088672 @default.
- W17332004 creator A5054274823 @default.
- W17332004 creator A5064653467 @default.
- W17332004 date "2000-07-25" @default.
- W17332004 modified "2023-09-25" @default.
- W17332004 title "Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of Type 2 diabetes mellitus" @default.
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