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• W1733811599 abstract "Amyloid-beta (Abeta) is cleared from the brain by both proteolytic digestion and transport across the blood-brain-barrier into the peripheral circulatory system. To investigate the role peripheral Abeta levels play in regulating Abeta brain clearance, we measured the clearance of [125I]-Abeta(1-40) injected into the brains of liver-ligated rats that allowed peripheral Abeta levels to be maintained at elevated levels for approximately one hour with/without a single peripheral bolus of unlabeled Abeta(1-40). We found that elevating peripheral Abetalevels significantly decreased [125I]-Abeta(1-40) brain clearance, thus supporting the hypothesis that peripheral Abeta levels regulate Abeta clearance from the central nervous system." @default.
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• W1733811599 date "2009-02-16" @default.
• W1733811599 modified "2023-10-12" @default.
• W1733811599 title "Peripheral Amyloid-β Levels Regulate Amyloid-β Clearance from the Central Nervous System" @default.
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• W1733811599 doi "https://doi.org/10.3233/jad-2009-0964" @default.
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