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- W173471185 abstract "Monocrotaline (MCT) is a toxic alkaloid that causes endothelial cell damage and lung injury resulting in pulmonary vascular remodeling and pulmonary hypertension (PH) in rats. Previous studies reported varying doses of MCT and body weight. We have now evaluated dose-response relationships in rats at varied initial body weights: (A=130–150 g; B=200–250 g; C=300–340 g) and 4 doses of MCT (40, 60, 80, 100 mg/kg). Outcome measures at 4 weeks post MCT included change in body weight, hemodynamics, morphological analysis and histology. The results showed that within each weight group the peak and mean PA pressure and PA:LV pressure ratio was significantly different than controls. Peak PA pressure was significantly different between groups B and C with doses 40 and 80 mg/kg (p=0.047 and p=0.002) respectively. Group C showed statistical significance between the 100 mg/kg when compared to the other 3 doses. Histology scores correlated directly with peak and mean PA pressure (r=0.47 for arterial wall thickening and r=0.61 for alveolar edema). An increased mortality was seen between weeks 3–4 in lower body weight groups (group A=83%, group B= 9%, group C= 2% mortality), necessitating obtaining new data at 3 weeks in group A. Liver histology results are pending. This study demonstrates a dose-response relationship between MCT, pulmonary hemodynamics and histology over an expanded dose initial weight range." @default.
- W173471185 created "2016-06-24" @default.
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- W173471185 date "2006-03-01" @default.
- W173471185 modified "2023-09-24" @default.
- W173471185 title "Dose Response Relationship in a Monocrotaline Rat Model of Pulmonary Hypertension" @default.
- W173471185 doi "https://doi.org/10.1096/fasebj.20.5.a1186" @default.
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