FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1734979942> ?p ?o ?g. }

• W1734979942 endingPage "1135" @default.
• W1734979942 startingPage "1124" @default.
• W1734979942 abstract "Rotigotine acts as a dopamine receptor agonist with high affinity for the dopamine D2, D3, D4 and D5 receptors but with a low affinity for the dopamine D1 receptor. We have investigated this further in radioligand binding and functional studies and compared the profile of rotigotine with that of other drugs used in the treatment of Parkinson's disease (PD).The binding of rotigotine to human dopamine D1, D2, D3, D4 and D5 receptors was determined in radioligand binding studies using [(3)H]rotigotine and compared with that of standard antagonist radioligands. Functional interactions of rotigotine with human dopamine receptors was also determined.[(3)H]rotigotine can be used as an agonist radioligand to label all dopamine receptor subtypes and this can be important to derive agonist affinity estimates. Rotigotine maintains this high affinity in functional studies at all dopamine receptors especially D1, D2 and D3 receptors and, to a lesser extent, D4 and D5 receptors. Rotigotine, like apomorphine but unlike ropinirole and pramipexole, was a potent agonist at all dopamine receptors.Rotigotine is a high-potency agonist at human dopamine D1, D2 and D3 receptors with a lower potency at D4 and D5 receptors. These studies differentiate rotigotine from conventional dopamine D2 agonists, used in the treatment of PD, such as ropinirole and pramipexole which lack activity at the D1 and D5 receptors, but resembles that of apomorphine which has greater efficacy in PD than other dopamine agonists but has suboptimal pharmacokinetic properties." @default.
• W1734979942 created "2016-06-24" @default.
• W1734979942 creator A5014005682 @default.
• W1734979942 creator A5051515087 @default.
• W1734979942 creator A5075556991 @default.
• W1734979942 creator A5087482611 @default.
• W1734979942 date "2015-01-13" @default.
• W1734979942 modified "2023-10-11" @default.
• W1734979942 title "Rotigotine is a potent agonist at dopamine D₁receptors as well as at dopamine D₂and D₃receptors" @default.
• W1734979942 cites W140972958 @default.
• W1734979942 cites W1541533178 @default.
• W1734979942 cites W1970668683 @default.
• W1734979942 cites W1971825415 @default.
• W1734979942 cites W1974026398 @default.
• W1734979942 cites W1974311568 @default.
• W1734979942 cites W1975481617 @default.
• W1734979942 cites W1978318953 @default.
• W1734979942 cites W1978390844 @default.
• W1734979942 cites W1980826200 @default.
• W1734979942 cites W1984432498 @default.
• W1734979942 cites W1997274212 @default.
• W1734979942 cites W2008851901 @default.
• W1734979942 cites W2009423131 @default.
• W1734979942 cites W2035937249 @default.
• W1734979942 cites W2038818280 @default.
• W1734979942 cites W2046179803 @default.
• W1734979942 cites W2049590247 @default.
• W1734979942 cites W2052426694 @default.
• W1734979942 cites W2054560340 @default.
• W1734979942 cites W2056198101 @default.
• W1734979942 cites W2063355775 @default.
• W1734979942 cites W2070048521 @default.
• W1734979942 cites W2070264532 @default.
• W1734979942 cites W2074631079 @default.
• W1734979942 cites W2082178571 @default.
• W1734979942 cites W2083884569 @default.
• W1734979942 cites W2094696231 @default.
• W1734979942 cites W2097744565 @default.
• W1734979942 cites W2121473111 @default.
• W1734979942 cites W2121835685 @default.
• W1734979942 cites W2126512783 @default.
• W1734979942 cites W2133608824 @default.
• W1734979942 cites W2139129258 @default.
• W1734979942 cites W2140864873 @default.
• W1734979942 cites W2155207556 @default.
• W1734979942 cites W2168954492 @default.
• W1734979942 cites W2169437499 @default.
• W1734979942 cites W2404147365 @default.
• W1734979942 cites W3167919470 @default.
• W1734979942 cites W4205572743 @default.
• W1734979942 cites W7862172 @default.
• W1734979942 doi "https://doi.org/10.1111/bph.12988" @default.
• W1734979942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4314200" @default.
• W1734979942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25339241" @default.
• W1734979942 hasPublicationYear "2015" @default.
• W1734979942 type Work @default.
• W1734979942 sameAs 1734979942 @default.
• W1734979942 citedByCount "73" @default.
• W1734979942 countsByYear W17349799422015 @default.
• W1734979942 countsByYear W17349799422016 @default.
• W1734979942 countsByYear W17349799422017 @default.
• W1734979942 countsByYear W17349799422018 @default.
• W1734979942 countsByYear W17349799422019 @default.
• W1734979942 countsByYear W17349799422020 @default.
• W1734979942 countsByYear W17349799422021 @default.
• W1734979942 countsByYear W17349799422022 @default.
• W1734979942 countsByYear W17349799422023 @default.
• W1734979942 crossrefType "journal-article" @default.
• W1734979942 hasAuthorship W1734979942A5014005682 @default.
• W1734979942 hasAuthorship W1734979942A5051515087 @default.
• W1734979942 hasAuthorship W1734979942A5075556991 @default.
• W1734979942 hasAuthorship W1734979942A5087482611 @default.
• W1734979942 hasBestOaLocation W17349799421 @default.
• W1734979942 hasConcept C120069818 @default.
• W1734979942 hasConcept C120750228 @default.
• W1734979942 hasConcept C126322002 @default.
• W1734979942 hasConcept C134018914 @default.
• W1734979942 hasConcept C137183658 @default.
• W1734979942 hasConcept C160262196 @default.
• W1734979942 hasConcept C170493617 @default.
• W1734979942 hasConcept C185592680 @default.
• W1734979942 hasConcept C199596767 @default.
• W1734979942 hasConcept C2777453868 @default.
• W1734979942 hasConcept C2777525119 @default.
• W1734979942 hasConcept C2778258207 @default.
• W1734979942 hasConcept C2778938600 @default.
• W1734979942 hasConcept C2779134260 @default.
• W1734979942 hasConcept C2779424955 @default.
• W1734979942 hasConcept C2779734285 @default.
• W1734979942 hasConcept C2779989193 @default.
• W1734979942 hasConcept C44208683 @default.
• W1734979942 hasConcept C513476851 @default.
• W1734979942 hasConcept C55493867 @default.
• W1734979942 hasConcept C67847695 @default.
• W1734979942 hasConcept C71924100 @default.
• W1734979942 hasConcept C86803240 @default.
• W1734979942 hasConcept C98274493 @default.
• W1734979942 hasConceptScore W1734979942C120069818 @default.

• next