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- W1735734236 endingPage "1183" @default.
- W1735734236 startingPage "1163" @default.
- W1735734236 abstract "Epithelial ovarian cancer (EOC) is the fourth commonest cause of female cancer death in the developed world. Although progress in treatment has improved survival, ∼ 80% of patients with advanced EOC will experience a recurrence and eventually will become resistant to chemotherapy. The aim of treatment for chemoresistant EOC has traditionally been limited to palliation of symptoms but the recent introduction of new therapies targeting molecular pathways is beginning to demonstrate improvements in disease control.This review provides an overview of early investigational drugs for the treatment of 'platinum-resistant' EOC. The article is based on English peer-reviewed articles located on MEDLINE and related abstracts presented at major international meetings.Drugs targeting several pathways are increasingly used to treat 'platinum-resistant' EOC. Currently, drugs targeting the angiogenesis pathway have been shown to significantly improve patient outcome. Studies are also being undertaken with inhibitors of poly(ADP-ribose) polymerase (PARP), targeting the DNA repair pathway as it is possible that the benefits seen with these agents in 'platinum-sensitive' disease will apply to those with 'platinum-resistant' disease. The discovery of predictive biomarkers that identify patients which benefit from these targeted therapies is paramount to the success of these treatments in the future." @default.
- W1735734236 created "2016-06-24" @default.
- W1735734236 creator A5073768160 @default.
- W1735734236 creator A5079383798 @default.
- W1735734236 creator A5088337563 @default.
- W1735734236 date "2015-07-24" @default.
- W1735734236 modified "2023-09-30" @default.
- W1735734236 title "An overview of early investigational therapies for chemoresistant ovarian cancer" @default.
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